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Natural-product-inspired design and synthesis of two series of compounds active against Trypanosoma cruzi: Insights into structure-activity relationship, toxicity, and mechanism of action.
da Rosa R, Dambrós BP, Höehr de Moraes M, Grand L, Jacolot M, Popowycz F, Steindel M, Schenkel EP, Campos Bernardes LS. da Rosa R, et al. Among authors: steindel m. Bioorg Chem. 2022 Feb;119:105492. doi: 10.1016/j.bioorg.2021.105492. Epub 2021 Nov 15. Bioorg Chem. 2022. PMID: 34838333
Synthesis, biological evaluation and SAR of sulfonamide 4-methoxychalcone derivatives with potential antileishmanial activity.
Andrighetti-Fröhner CR, de Oliveira KN, Gaspar-Silva D, Pacheco LK, Joussef AC, Steindel M, Simões CM, de Souza AM, Magalhaes UO, Afonso IF, Rodrigues CR, Nunes RJ, Castro HC. Andrighetti-Fröhner CR, et al. Among authors: steindel m. Eur J Med Chem. 2009 Feb;44(2):755-63. doi: 10.1016/j.ejmech.2008.04.016. Epub 2008 May 6. Eur J Med Chem. 2009. PMID: 18554753
Trimethoxy-chalcone derivatives inhibit growth of Leishmania braziliensis: synthesis, biological evaluation, molecular modeling and structure-activity relationship (SAR).
Bello ML, Chiaradia LD, Dias LR, Pacheco LK, Stumpf TR, Mascarello A, Steindel M, Yunes RA, Castro HC, Nunes RJ, Rodrigues CR. Bello ML, et al. Among authors: steindel m. Bioorg Med Chem. 2011 Aug 15;19(16):5046-52. doi: 10.1016/j.bmc.2011.06.023. Epub 2011 Jun 21. Bioorg Med Chem. 2011. PMID: 21757358
Anti-infective potential of marine invertebrates and seaweeds from the Brazilian coast.
Bianco EM, de Oliveira SQ, Rigotto C, Tonini ML, da Rosa Guimarães T, Bittencourt F, Gouvêa LP, Aresi C, de Almeida MT, Moritz MI, Martins CD, Scherner F, Carraro JL, Horta PA, Reginatto FH, Steindel M, Simões CM, Schenkel EP. Bianco EM, et al. Among authors: steindel m. Molecules. 2013 May 16;18(5):5761-78. doi: 10.3390/molecules18055761. Molecules. 2013. PMID: 23681060 Free PMC article.
Synthesis and 2D-QSAR studies of neolignan-based diaryl-tetrahydrofuran and -furan analogues with remarkable activity against Trypanosoma cruzi and assessment of the trypanothione reductase activity.
Hartmann AP, de Carvalho MR, Bernardes LSC, Moraes MH, de Melo EB, Lopes CD, Steindel M, da Silva JS, Carvalho I. Hartmann AP, et al. Among authors: steindel m. Eur J Med Chem. 2017 Nov 10;140:187-199. doi: 10.1016/j.ejmech.2017.08.064. Epub 2017 Sep 4. Eur J Med Chem. 2017. PMID: 28926763
124 results