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STMN1 is highly expressed and contributes to clonogenicity in acute promyelocytic leukemia cells.
Vicari HP, Coelho-Silva JL, Pereira-Martins DA, Lucena-Araujo AR, Lima K, Lipreri da Silva JC, Scheucher PS, Koury LC, de Melo RA, Bittencourt R, Pagnano K, Nunes E, Fagundes EM, Kerbauy F, de Figueiredo-Pontes LL, Costa-Lotufo LV, Rego EM, Traina F, Machado-Neto JA. Vicari HP, et al. Among authors: scheucher ps. Invest New Drugs. 2022 Apr;40(2):438-452. doi: 10.1007/s10637-021-01197-0. Epub 2021 Nov 27. Invest New Drugs. 2022. PMID: 34837603
NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia.
Thomé CH, Ferreira GA, Pereira-Martins DA, Dos Santos GA, Ortiz CA, de Souza LEB, Sobral LM, Silva CLA, Scheucher PS, Gil CD, Leopoldino AM, Silveira DRA, Coelho-Silva JL, Traina F, Koury LC, Melo RAM, Bittencourt R, Pagnano K, Pasquini R, Nunes EC, Fagundes EM, Gloria ABF, Kerbauy FR, Chauffaille ML, Keating A, Tallman MS, Ribeiro RC, Dillon R, Ganser A, Löwenberg B, Valk P, Lo-Coco F, Sanz MA, Berliner N, Faça VM, Rego EM. Thomé CH, et al. Among authors: scheucher ps. Sci Rep. 2020 Jun 25;10(1):10315. doi: 10.1038/s41598-020-66223-2. Sci Rep. 2020. PMID: 32587277 Free PMC article.
NT157, an IGF1R-IRS1/2 inhibitor, exhibits antineoplastic effects in pre-clinical models of chronic myeloid leukemia.
Scopim-Ribeiro R, Machado-Neto JA, Eide CA, Coelho-Silva JL, Fenerich BA, Fernandes JC, Scheucher PS, Savage Stevens SL, de Melo Campos P, Olalla Saad ST, de Carvalho Palma L, de Figueiredo-Pontes LL, Simões BP, Rego EM, Tognon CE, Druker BJ, Traina F. Scopim-Ribeiro R, et al. Among authors: scheucher ps. Invest New Drugs. 2021 Jun;39(3):736-746. doi: 10.1007/s10637-020-01028-8. Epub 2021 Jan 6. Invest New Drugs. 2021. PMID: 33403501
Phenformin increases early hematopoietic progenitors in the Jak2V617F murine model.
Alves-Silva AB, Fenerich BA, Fonseca NP, Fernandes JC, Coelho-Silva JL, Pereira-Martins DA, Bianco TM, Scheucher PS, Rego EM, Chahud F, Machado-Neto JA, Figueiredo-Pontes LL, Traina F. Alves-Silva AB, et al. Among authors: scheucher ps. Invest New Drugs. 2022 Jun;40(3):576-585. doi: 10.1007/s10637-022-01212-y. Epub 2022 Jan 11. Invest New Drugs. 2022. PMID: 35015172
ΔNp73 overexpression promotes resistance to apoptosis but does not cooperate with PML/RARA in the induction of an APL-leukemic phenotype.
Lucena-Araujo AR, Coelho-Silva JL, Pereira-Martins DA, Thomé C, Scheucher PS, Lange AP, Paiva HH, Hemmelgarn BT, Morais-Sobral MC, Azevedo EA, Franca-Neto PL, Franca RF, Silva CL, Krause A, Rego EM. Lucena-Araujo AR, et al. Among authors: scheucher ps. Oncotarget. 2017 Jan 31;8(5):8475-8483. doi: 10.18632/oncotarget.14295. Oncotarget. 2017. PMID: 28035072 Free PMC article.
Apoptosis induction by (+)alpha-tocopheryl succinate in the absence or presence of all-trans retinoic acid and arsenic trioxide in NB4, NB4-R2 and primary APL cells.
Freitas RA, Silva dos Santos GA, Gimenes Teixeira HL, Scheucher PS, Lucena-Araujo AR, Lima AS, Abreu e Lima RS, Garcia AB, Jordão AA Jr, Falcão RP, Vannucchi H, Rego EM. Freitas RA, et al. Among authors: scheucher ps. Leuk Res. 2009 Jul;33(7):958-63. doi: 10.1016/j.leukres.2008.09.035. Epub 2008 Nov 14. Leuk Res. 2009. PMID: 19013639
Reversine triggers mitotic catastrophe and apoptosis in K562 cells.
Rodrigues Alves AP, Machado-Neto JA, Scheucher PS, Paiva HH, Simões BP, Rego EM, Traina F. Rodrigues Alves AP, et al. Among authors: scheucher ps. Leuk Res. 2016 Sep;48:26-31. doi: 10.1016/j.leukres.2016.06.011. Epub 2016 Jul 1. Leuk Res. 2016. PMID: 27447890
Paclitaxel induces Stathmin 1 phosphorylation, microtubule stability and apoptosis in acute lymphoblastic leukemia cells.
Machado-Neto JA, Rodrigues Alves APN, Fernandes JC, Coelho-Silva JL, Scopim-Ribeiro R, Fenerich BA, da Silva FB, Scheucher PS, Simões BP, Rego EM, Traina F. Machado-Neto JA, et al. Among authors: scheucher ps. Heliyon. 2017 Sep 28;3(9):e00405. doi: 10.1016/j.heliyon.2017.e00405. eCollection 2017 Sep. Heliyon. 2017. PMID: 29034341 Free PMC article.
Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms.
Machado-Neto JA, Fenerich BA, Scopim-Ribeiro R, Eide CA, Coelho-Silva JL, Dechandt CRP, Fernandes JC, Rodrigues Alves APN, Scheucher PS, Simões BP, Alberici LC, de Figueiredo Pontes LL, Tognon CE, Druker BJ, Rego EM, Traina F. Machado-Neto JA, et al. Among authors: scheucher ps. Cell Death Dis. 2018 Feb 22;9(3):311. doi: 10.1038/s41419-017-0256-4. Cell Death Dis. 2018. PMID: 29472557 Free PMC article.
28 results