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High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis.
Stijlemans B, Caljon G, Natesan SK, Saerens D, Conrath K, Pérez-Morga D, Skepper JN, Nikolaou A, Brys L, Pays E, Magez S, Field MC, De Baetselier P, Muyldermans S. Stijlemans B, et al. Among authors: brys l. PLoS Pathog. 2011 Jun;7(6):e1002072. doi: 10.1371/journal.ppat.1002072. Epub 2011 Jun 16. PLoS Pathog. 2011. PMID: 21698216 Free PMC article.
M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment.
Van Overmeire E, Stijlemans B, Heymann F, Keirsse J, Morias Y, Elkrim Y, Brys L, Abels C, Lahmar Q, Ergen C, Vereecke L, Tacke F, De Baetselier P, Van Ginderachter JA, Laoui D. Van Overmeire E, et al. Among authors: brys l. Cancer Res. 2016 Jan 1;76(1):35-42. doi: 10.1158/0008-5472.CAN-15-0869. Epub 2015 Nov 16. Cancer Res. 2016. PMID: 26573801
Novel half-life extended anti-MIF nanobodies protect against endotoxic shock.
Sparkes A, De Baetselier P, Brys L, Cabrito I, Sterckx YG, Schoonooghe S, Muyldermans S, Raes G, Bucala R, Vanlandschoot P, Van Ginderachter JA, Stijlemans B. Sparkes A, et al. Among authors: brys l. FASEB J. 2018 Jun;32(6):3411-3422. doi: 10.1096/fj.201701189R. Epub 2018 Jan 25. FASEB J. 2018. PMID: 29401625 Free PMC article.
Q586B2 is a crucial virulence factor during the early stages of Trypanosoma brucei infection that is conserved amongst trypanosomatids.
Stijlemans B, De Baetselier P, Van Molle I, Lecordier L, Hendrickx E, Romão E, Vincke C, Baetens W, Schoonooghe S, Hassanzadeh-Ghassabeh G, Korf H, Wallays M, Pinto Torres JE, Perez-Morga D, Brys L, Campetella O, Leguizamón MS, Claes M, Hendrickx S, Mabille D, Caljon G, Remaut H, Roelants K, Magez S, Van Ginderachter JA, De Trez C. Stijlemans B, et al. Among authors: brys l. Nat Commun. 2024 Feb 27;15(1):1779. doi: 10.1038/s41467-024-46067-4. Nat Commun. 2024. PMID: 38413606 Free PMC article.
59 results