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Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer.
Joshi S, Gomes ED, Wang T, Corben A, Taldone T, Gandu S, Xu C, Sharma S, Buddaseth S, Yan P, Chan LYL, Gokce A, Rajasekhar VK, Shrestha L, Panchal P, Almodovar J, Digwal CS, Rodina A, Merugu S, Pillarsetty N, Miclea V, Peter RI, Wang W, Ginsberg SD, Tang L, Mattar M, de Stanchina E, Yu KH, Lowery M, Grbovic-Huezo O, O'Reilly EM, Janjigian Y, Healey JH, Jarnagin WR, Allen PJ, Sander C, Erdjument-Bromage H, Neubert TA, Leach SD, Chiosis G. Joshi S, et al. Among authors: leach sd. Commun Biol. 2021 Nov 25;4(1):1333. doi: 10.1038/s42003-021-02842-3. Commun Biol. 2021. PMID: 34824367 Free PMC article.
Unbiased in vivo preclinical evaluation of anticancer drugs identifies effective therapy for the treatment of pancreatic adenocarcinoma.
Grbovic-Huezo O, Pitter KL, Lecomte N, Saglimbeni J, Askan G, Holm M, Melchor JP, Chandwani R, Joshi S, Haglund C, Iacobuzio-Donahue CA, Chiosis G, Tammela T, Leach SD. Grbovic-Huezo O, et al. Among authors: leach sd. Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30670-30678. doi: 10.1073/pnas.1920240117. Epub 2020 Nov 16. Proc Natl Acad Sci U S A. 2020. PMID: 33199632 Free PMC article.
Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype.
Lowery MA, Jordan EJ, Basturk O, Ptashkin RN, Zehir A, Berger MF, Leach T, Herbst B, Askan G, Maynard H, Glassman D, Covington C, Schultz N, Abou-Alfa GK, Harding JJ, Klimstra DS, Hechtman JF, Hyman DM, Allen PJ, Jarnagin WR, Balachandran VP, Varghese AM, Schattner MA, Yu KH, Saltz LB, Solit DB, Iacobuzio-Donahue CA, Leach SD, O'Reilly EM. Lowery MA, et al. Among authors: leach sd, leach t. Clin Cancer Res. 2017 Oct 15;23(20):6094-6100. doi: 10.1158/1078-0432.CCR-17-0899. Epub 2017 Jul 28. Clin Cancer Res. 2017. PMID: 28754816
Tumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner.
Latario CJ, Schoenfeld LW, Howarth CL, Pickrell LE, Begum F, Fischer DA, Grbovic-Huezo O, Leach SD, Sanchez Y, Smith KD, Higgs HN. Latario CJ, et al. Among authors: leach sd. Mol Biol Cell. 2020 Jun 1;31(12):1259-1272. doi: 10.1091/mbc.E19-11-0605. Epub 2020 Apr 8. Mol Biol Cell. 2020. PMID: 32267199 Free PMC article.
Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules.
Singh K, Lin J, Lecomte N, Mohan P, Gokce A, Sanghvi VR, Jiang M, Grbovic-Huezo O, Burčul A, Stark SG, Romesser PB, Chang Q, Melchor JP, Beyer RK, Duggan M, Fukase Y, Yang G, Ouerfelli O, Viale A, de Stanchina E, Stamford AW, Meinke PT, Rätsch G, Leach SD, Ouyang Z, Wendel HG. Singh K, et al. Among authors: leach sd. Cancer Res. 2021 Apr 15;81(8):2002-2014. doi: 10.1158/0008-5472.CAN-20-2929. Epub 2021 Feb 25. Cancer Res. 2021. PMID: 33632898 Free PMC article.
Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing.
Mandelker D, Zhang L, Kemel Y, Stadler ZK, Joseph V, Zehir A, Pradhan N, Arnold A, Walsh MF, Li Y, Balakrishnan AR, Syed A, Prasad M, Nafa K, Carlo MI, Cadoo KA, Sheehan M, Fleischut MH, Salo-Mullen E, Trottier M, Lipkin SM, Lincoln A, Mukherjee S, Ravichandran V, Cambria R, Galle J, Abida W, Arcila ME, Benayed R, Shah R, Yu K, Bajorin DF, Coleman JA, Leach SD, Lowery MA, Garcia-Aguilar J, Kantoff PW, Sawyers CL, Dickler MN, Saltz L, Motzer RJ, O'Reilly EM, Scher HI, Baselga J, Klimstra DS, Solit DB, Hyman DM, Berger MF, Ladanyi M, Robson ME, Offit K. Mandelker D, et al. Among authors: leach sd. JAMA. 2017 Sep 5;318(9):825-835. doi: 10.1001/jama.2017.11137. JAMA. 2017. PMID: 28873162 Free PMC article.
Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms.
Lowery MA, Wong W, Jordan EJ, Lee JW, Kemel Y, Vijai J, Mandelker D, Zehir A, Capanu M, Salo-Mullen E, Arnold AG, Yu KH, Varghese AM, Kelsen DP, Brenner R, Kaufmann E, Ravichandran V, Mukherjee S, Berger MF, Hyman DM, Klimstra DS, Abou-Alfa GK, Tjan C, Covington C, Maynard H, Allen PJ, Askan G, Leach SD, Iacobuzio-Donahue CA, Robson ME, Offit K, Stadler ZK, O'Reilly EM. Lowery MA, et al. Among authors: leach sd. J Natl Cancer Inst. 2018 Oct 1;110(10):1067-1074. doi: 10.1093/jnci/djy024. J Natl Cancer Inst. 2018. PMID: 29506128 Free PMC article.
ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer.
Huang YH, Hu J, Chen F, Lecomte N, Basnet H, David CJ, Witkin MD, Allen PJ, Leach SD, Hollmann TJ, Iacobuzio-Donahue CA, Massagué J. Huang YH, et al. Among authors: leach sd. Cancer Discov. 2020 Jan;10(1):142-157. doi: 10.1158/2159-8290.CD-19-0529. Epub 2019 Oct 3. Cancer Discov. 2020. PMID: 31582374 Free PMC article.
Co-inhibition of SMAD and MAPK signaling enhances 124I uptake in BRAF-mutant thyroid cancers.
Luckett KA, Cracchiolo JR, Krishnamoorthy GP, Leandro-Garcia LJ, Nagarajah J, Saqcena M, Lester R, Im SY, Zhao Z, Lowe SW, de Stanchina E, Sherman EJ, Ho AL, Leach SD, Knauf JA, Fagin JA. Luckett KA, et al. Among authors: leach sd. Endocr Relat Cancer. 2021 May 18;28(6):391-402. doi: 10.1530/ERC-21-0017. Endocr Relat Cancer. 2021. PMID: 33890869 Free PMC article.
166 results