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Hexavalent sperm-binding IgG antibody released from vaginal film for development of potent on-demand nonhormonal female contraception.
Shrestha B, Vincent K, Schaefer A, Zhu Y, Vargas G, Motamedi M, Swope K, Morton J, Simpson C, Pham H, Brennan MB, Pauly MH, Zeitlin L, Bratcher B, Whaley KJ, Moench TR, Lai SK. Shrestha B, et al. Among authors: moench tr. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2107832118. doi: 10.1073/pnas.2107832118. Proc Natl Acad Sci U S A. 2021. PMID: 34815336 Free PMC article.
Safety, acceptability, and pharmacokinetics of a monoclonal antibody-based vaginal multipurpose prevention film (MB66): A Phase I randomized trial.
Politch JA, Cu-Uvin S, Moench TR, Tashima KT, Marathe JG, Guthrie KM, Cabral H, Nyhuis T, Brennan M, Zeitlin L, Spiegel HML, Mayer KH, Whaley KJ, Anderson DJ. Politch JA, et al. Among authors: moench tr. PLoS Med. 2021 Feb 3;18(2):e1003495. doi: 10.1371/journal.pmed.1003495. eCollection 2021 Feb. PLoS Med. 2021. PMID: 33534791 Free PMC article. Clinical Trial.
Pharmacokinetics and Preliminary Safety of Pod-Intravaginal Rings Delivering the Monoclonal Antibody VRC01-N for HIV Prophylaxis in a Macaque Model.
Zhao C, Gunawardana M, Villinger F, Baum MM, Remedios-Chan M, Moench TR, Zeitlin L, Whaley KJ, Bohorov O, Smith TJ, Anderson DJ, Moss JA. Zhao C, et al. Among authors: moench tr. Antimicrob Agents Chemother. 2017 Jun 27;61(7):e02465-16. doi: 10.1128/AAC.02465-16. Print 2017 Jul. Antimicrob Agents Chemother. 2017. PMID: 28416548 Free PMC article.
Human monoclonal antibody stability and activity at vaginal pH.
Castle PE, Karp DA, Zeitlin L, García-Moreno E B, Moench TR, Whaley KJ, Cone RA. Castle PE, et al. Among authors: moench tr. J Reprod Immunol. 2002 Jul-Aug;56(1-2):61-76. doi: 10.1016/s0165-0378(02)00013-x. J Reprod Immunol. 2002. PMID: 12106884
96 results