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ERK5 Inhibition Induces Autophagy-Mediated Cancer Cell Death by Activating ER Stress.
Front Cell Dev Biol. 2021 Nov 4;9:742049. doi: 10.3389/fcell.2021.742049. eCollection 2021.
Front Cell Dev Biol. 2021.
PMID: 34805151
Free PMC article.
The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells.
Muñoz-Guardiola P, Casas J, Megías-Roda E, Solé S, Perez-Montoyo H, Yeste-Velasco M, Erazo T, Diéguez-Martínez N, Espinosa-Gil S, Muñoz-Pinedo C, Yoldi G, Abad JL, Segura MF, Moran T, Romeo M, Bosch-Barrera J, Oaknin A, Alfón J, Domènech C, Fabriàs G, Velasco G, Lizcano JM.
Muñoz-Guardiola P, et al. Among authors: dieguez martinez n.
Autophagy. 2021 Jun;17(6):1349-1366. doi: 10.1080/15548627.2020.1761651. Epub 2020 May 25.
Autophagy. 2021.
PMID: 32397857
Free PMC article.
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SUMOylation Is Required for ERK5 Nuclear Translocation and ERK5-Mediated Cancer Cell Proliferation.
Erazo T, Espinosa-Gil S, Diéguez-Martínez N, Gómez N, Lizcano JM.
Erazo T, et al. Among authors: dieguez martinez n.
Int J Mol Sci. 2020 Mar 23;21(6):2203. doi: 10.3390/ijms21062203.
Int J Mol Sci. 2020.
PMID: 32209980
Free PMC article.
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The ERK5/NF-κB signaling pathway targets endometrial cancer proliferation and survival.
Diéguez-Martínez N, Espinosa-Gil S, Yoldi G, Megías-Roda E, Bolinaga-Ayala I, Viñas-Casas M, Gorgisen G, Domingo-Ortí I, Pérez-Montoyo H, Bayascas JR, Colas E, Dolcet X, Lizcano JM.
Diéguez-Martínez N, et al.
Cell Mol Life Sci. 2022 Sep 19;79(10):524. doi: 10.1007/s00018-022-04541-6.
Cell Mol Life Sci. 2022.
PMID: 36123565
Free PMC article.
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An ERK5-KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells.
Brown HA, Williams CAC, Zhou H, Rios-Szwed D, Fernandez-Alonso R, Mansoor S, McMulkin L, Toth R, Gourlay R, Peltier J, Dieguez-Martinez N, Trost M, Lizcano JM, Stavridis MP, Findlay GM.
Brown HA, et al. Among authors: dieguez martinez n.
Biochem J. 2021 Dec 10;478(23):4119-4136. doi: 10.1042/BCJ20210646.
Biochem J. 2021.
PMID: 34780645
Free PMC article.
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Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.
Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, Becht K, Kim ND, McKeown MR, Roberts JM, Zhang J, Sim T, Alessi DR, Bradner JE, Lizcano JM, Blacklow SC, Qi J, Xu X, Gray NS.
Wang J, et al. Among authors: dieguez martinez n.
ACS Chem Biol. 2018 Sep 21;13(9):2438-2448. doi: 10.1021/acschembio.7b00638. Epub 2018 Aug 31.
ACS Chem Biol. 2018.
PMID: 30102854
Free PMC article.
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Discovery of a selective inhibitor of doublecortin like kinase 1.
Ferguson FM, Nabet B, Raghavan S, Liu Y, Leggett AL, Kuljanin M, Kalekar RL, Yang A, He S, Wang J, Ng RWS, Sulahian R, Li L, Poulin EJ, Huang L, Koren J, Dieguez-Martinez N, Espinosa S, Zeng Z, Corona CR, Vasta JD, Ohi R, Sim T, Kim ND, Harshbarger W, Lizcano JM, Robers MB, Muthaswamy S, Lin CY, Look AT, Haigis KM, Mancias JD, Wolpin BM, Aguirre AJ, Hahn WC, Westover KD, Gray NS.
Ferguson FM, et al. Among authors: dieguez martinez n.
Nat Chem Biol. 2020 Jun;16(6):635-643. doi: 10.1038/s41589-020-0506-0. Epub 2020 Apr 6.
Nat Chem Biol. 2020.
PMID: 32251410
Free PMC article.
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