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Discovery and Development of Cyclic Peptide Inhibitors of CIB1.
Haberman VA, Fleming SR, Leisner TM, Puhl AC, Feng E, Xie L, Chen X, Goto Y, Suga H, Parise LV, Kireev D, Pearce KH, Bowers AA. Haberman VA, et al. Among authors: bowers aa. ACS Med Chem Lett. 2021 Oct 27;12(11):1832-1839. doi: 10.1021/acsmedchemlett.1c00438. eCollection 2021 Nov 11. ACS Med Chem Lett. 2021. PMID: 34795874 Free PMC article.
Flexizyme-Enabled Benchtop Biosynthesis of Thiopeptides.
Fleming SR, Bartges TE, Vinogradov AA, Kirkpatrick CL, Goto Y, Suga H, Hicks LM, Bowers AA. Fleming SR, et al. Among authors: bowers aa. J Am Chem Soc. 2019 Jan 16;141(2):758-762. doi: 10.1021/jacs.8b11521. Epub 2019 Jan 8. J Am Chem Soc. 2019. PMID: 30602112 Free PMC article.
Exploring the Post-translational Enzymology of PaaA by mRNA Display.
Fleming SR, Himes PM, Ghodge SV, Goto Y, Suga H, Bowers AA. Fleming SR, et al. Among authors: bowers aa. J Am Chem Soc. 2020 Mar 18;142(11):5024-5028. doi: 10.1021/jacs.0c01576. Epub 2020 Mar 6. J Am Chem Soc. 2020. PMID: 32109054 Free PMC article.
mRNA Display Reaches for the Clinic with New PCSK9 Inhibitor.
Iskandar SE, Bowers AA. Iskandar SE, et al. Among authors: bowers aa. ACS Med Chem Lett. 2022 Aug 26;13(9):1379-1383. doi: 10.1021/acsmedchemlett.2c00319. eCollection 2022 Sep 8. ACS Med Chem Lett. 2022. PMID: 36105330 Free PMC article.
Identification of Covalent Cyclic Peptide Inhibitors in mRNA Display.
Iskandar SE, Chiou LF, Leisner TM, Shell DJ, Norris-Drouin JL, Vaziri C, Pearce KH, Bowers AA. Iskandar SE, et al. Among authors: bowers aa. J Am Chem Soc. 2023 Jul 19;145(28):15065-15070. doi: 10.1021/jacs.3c04833. Epub 2023 Jul 3. J Am Chem Soc. 2023. PMID: 37395736
Cheminformatics-Guided Cell-Free Exploration of Peptide Natural Products.
Pelton JM, Hochuli JE, Sadecki PW, Katoh T, Suga H, Hicks LM, Muratov EN, Tropsha A, Bowers AA. Pelton JM, et al. Among authors: bowers aa. J Am Chem Soc. 2024 Mar 27;146(12):8016-8030. doi: 10.1021/jacs.3c11306. Epub 2024 Mar 12. J Am Chem Soc. 2024. PMID: 38470819
73 results