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Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones.
Maes C, Goossens S, Bartunkova S, Drogat B, Coenegrachts L, Stockmans I, Moermans K, Nyabi O, Haigh K, Naessens M, Haenebalcke L, Tuckermann JP, Tjwa M, Carmeliet P, Mandic V, David JP, Behrens A, Nagy A, Carmeliet G, Haigh JJ. Maes C, et al. Among authors: tuckermann jp. EMBO J. 2010 Jan 20;29(2):424-41. doi: 10.1038/emboj.2009.361. Epub 2009 Dec 10. EMBO J. 2010. PMID: 20010698 Free PMC article.
Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor.
Rauch A, Seitz S, Baschant U, Schilling AF, Illing A, Stride B, Kirilov M, Mandic V, Takacz A, Schmidt-Ullrich R, Ostermay S, Schinke T, Spanbroek R, Zaiss MM, Angel PE, Lerner UH, David JP, Reichardt HM, Amling M, Schütz G, Tuckermann JP. Rauch A, et al. Cell Metab. 2010 Jun 9;11(6):517-31. doi: 10.1016/j.cmet.2010.05.005. Cell Metab. 2010. PMID: 20519123 Free article.
Elevated Fra-1 expression causes severe lipodystrophy.
Luther J, Driessler F, Megges M, Hess A, Herbort B, Mandic V, Zaiss MM, Reichardt A, Zech C, Tuckermann JP, Calkhoven CF, Wagner EF, Schett G, David JP. Luther J, et al. Among authors: tuckermann jp. J Cell Sci. 2011 May 1;124(Pt 9):1465-76. doi: 10.1242/jcs.079855. Epub 2011 Apr 12. J Cell Sci. 2011. PMID: 21486951
RSK2 protects mice against TNF-induced bone loss.
Böhm C, Derer A, Axmann R, Hillienhoff U, Zaiss MM, Luther J, Zech C, Stock M, Scholtysek C, Engelke K, Hess A, Tuckermann JP, Schett G, David JP. Böhm C, et al. Among authors: tuckermann jp. J Cell Sci. 2012 May 1;125(Pt 9):2160-71. doi: 10.1242/jcs.096008. Epub 2012 Feb 17. J Cell Sci. 2012. PMID: 22344264
PPARβ/δ governs Wnt signaling and bone turnover.
Scholtysek C, Katzenbeisser J, Fu H, Uderhardt S, Ipseiz N, Stoll C, Zaiss MM, Stock M, Donhauser L, Böhm C, Kleyer A, Hess A, Engelke K, David JP, Djouad F, Tuckermann JP, Desvergne B, Schett G, Krönke G. Scholtysek C, et al. Among authors: tuckermann jp. Nat Med. 2013 May;19(5):608-13. doi: 10.1038/nm.3146. Epub 2013 Mar 31. Nat Med. 2013. PMID: 23542786
Loss of menin in osteoblast lineage affects osteocyte-osteoclast crosstalk causing osteoporosis.
Liu P, Lee S, Knoll J, Rauch A, Ostermay S, Luther J, Malkusch N, Lerner UH, Zaiss MM, Neven M, Wittig R, Rauner M, David JP, Bertolino P, Zhang CX, Tuckermann JP. Liu P, et al. Among authors: tuckermann jp. Cell Death Differ. 2017 Apr;24(4):672-682. doi: 10.1038/cdd.2016.165. Epub 2017 Jan 20. Cell Death Differ. 2017. PMID: 28106886 Free PMC article.
189 results