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The mitochondrial regulator PGC1α is induced by cGMP-PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure.
Zhu G, Ueda K, Hashimoto M, Zhang M, Sasaki M, Kariya T, Sasaki H, Kaludercic N, Lee DI, Bedja D, Gabrielson M, Yuan Y, Paolocci N, Blanton RM, Karas RH, Mendelsohn ME, O'Rourke B, Kass DA, Takimoto E. Zhu G, et al. Among authors: sasaki h, sasaki m. FEBS Lett. 2022 Jan;596(1):17-28. doi: 10.1002/1873-3468.14228. Epub 2021 Nov 19. FEBS Lett. 2022. PMID: 34778969 Free PMC article.
PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress.
Ranek MJ, Kokkonen-Simon KM, Chen A, Dunkerly-Eyring BL, Vera MP, Oeing CU, Patel CH, Nakamura T, Zhu G, Bedja D, Sasaki M, Holewinski RJ, Van Eyk JE, Powell JD, Lee DI, Kass DA. Ranek MJ, et al. Among authors: sasaki m. Nature. 2019 Feb;566(7743):264-269. doi: 10.1038/s41586-019-0895-y. Epub 2019 Jan 30. Nature. 2019. PMID: 30700906 Free PMC article.
CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury.
Ranek MJ, Oeing C, Sanchez-Hodge R, Kokkonen-Simon KM, Dillard D, Aslam MI, Rainer PP, Mishra S, Dunkerly-Eyring B, Holewinski RJ, Virus C, Zhang H, Mannion MM, Agrawal V, Hahn V, Lee DI, Sasaki M, Van Eyk JE, Willis MS, Page RC, Schisler JC, Kass DA. Ranek MJ, et al. Among authors: sasaki m. Nat Commun. 2020 Oct 20;11(1):5237. doi: 10.1038/s41467-020-18980-x. Nat Commun. 2020. PMID: 33082318 Free PMC article.
Poly(ADP-ribose) (PAR) polymer is a death signal.
Andrabi SA, Kim NS, Yu SW, Wang H, Koh DW, Sasaki M, Klaus JA, Otsuka T, Zhang Z, Koehler RC, Hurn PD, Poirier GG, Dawson VL, Dawson TM. Andrabi SA, et al. Among authors: sasaki m. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18308-13. doi: 10.1073/pnas.0606526103. Epub 2006 Nov 20. Proc Natl Acad Sci U S A. 2006. PMID: 17116882 Free PMC article.
AIF3 splicing switch triggers neurodegeneration.
Liu S, Zhou M, Ruan Z, Wang Y, Chang C, Sasaki M, Rajaram V, Lemoff A, Nambiar K, Wang JE, Hatanpaa KJ, Luo W, Dawson TM, Dawson VL, Wang Y. Liu S, et al. Among authors: sasaki m. Mol Neurodegener. 2021 Apr 14;16(1):25. doi: 10.1186/s13024-021-00442-7. Mol Neurodegener. 2021. PMID: 33853653 Free PMC article.
5,973 results