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The mitochondrial regulator PGC1α is induced by cGMP-PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure.
Zhu G, Ueda K, Hashimoto M, Zhang M, Sasaki M, Kariya T, Sasaki H, Kaludercic N, Lee DI, Bedja D, Gabrielson M, Yuan Y, Paolocci N, Blanton RM, Karas RH, Mendelsohn ME, O'Rourke B, Kass DA, Takimoto E. Zhu G, et al. FEBS Lett. 2022 Jan;596(1):17-28. doi: 10.1002/1873-3468.14228. Epub 2021 Nov 19. FEBS Lett. 2022. PMID: 34778969 Free PMC article.
Cellular and molecular determinants of altered Ca2+ handling in the failing rabbit heart: primary defects in SR Ca2+ uptake and release mechanisms.
Armoundas AA, Rose J, Aggarwal R, Stuyvers BD, O'rourke B, Kass DA, Marbán E, Shorofsky SR, Tomaselli GF, William Balke C. Armoundas AA, et al. Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1607-18. doi: 10.1152/ajpheart.00525.2006. Epub 2006 Nov 22. Am J Physiol Heart Circ Physiol. 2007. PMID: 17122195 Free PMC article.
350 results