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The mitochondrial regulator PGC1α is induced by cGMP-PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure.
Zhu G, Ueda K, Hashimoto M, Zhang M, Sasaki M, Kariya T, Sasaki H, Kaludercic N, Lee DI, Bedja D, Gabrielson M, Yuan Y, Paolocci N, Blanton RM, Karas RH, Mendelsohn ME, O'Rourke B, Kass DA, Takimoto E. Zhu G, et al. Among authors: karas rh. FEBS Lett. 2022 Jan;596(1):17-28. doi: 10.1002/1873-3468.14228. Epub 2021 Nov 19. FEBS Lett. 2022. PMID: 34778969 Free PMC article.
PDE5 inhibitor efficacy is estrogen dependent in female heart disease.
Sasaki H, Nagayama T, Blanton RM, Seo K, Zhang M, Zhu G, Lee DI, Bedja D, Hsu S, Tsukamoto O, Takashima S, Kitakaze M, Mendelsohn ME, Karas RH, Kass DA, Takimoto E. Sasaki H, et al. Among authors: karas rh. J Clin Invest. 2014 Jun;124(6):2464-71. doi: 10.1172/JCI70731. Epub 2014 May 16. J Clin Invest. 2014. PMID: 24837433 Free PMC article.
Rapid progress for non-nuclear estrogen receptor signaling.
Mendelsohn ME, Karas RH. Mendelsohn ME, et al. Among authors: karas rh. J Clin Invest. 2010 Jul;120(7):2277-9. doi: 10.1172/JCI43756. Epub 2010 Jun 23. J Clin Invest. 2010. PMID: 20577045 Free PMC article. Review.
Mutation of the protein kinase I alpha leucine zipper domain produces hypertension and progressive left ventricular hypertrophy: a novel mouse model of age-dependent hypertensive heart disease.
Blanton RM, Takimoto E, Aronovitz M, Thoonen R, Kass DA, Karas RH, Mendelsohn ME. Blanton RM, et al. Among authors: karas rh. J Gerontol A Biol Sci Med Sci. 2013 Nov;68(11):1351-5. doi: 10.1093/gerona/glt042. Epub 2013 May 8. J Gerontol A Biol Sci Med Sci. 2013. PMID: 23657971 Free PMC article.
210 results