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Picomolar inhibition of SARS-CoV-2 variants of concern by an engineered ACE2-IgG4-Fc fusion protein.
Antiviral Res. 2021 Dec;196:105197. doi: 10.1016/j.antiviral.2021.105197. Epub 2021 Nov 10.
Antiviral Res. 2021.
PMID: 34774603
Free PMC article.
Evaluation of a Fully Human, Hepatitis B Virus-Specific Chimeric Antigen Receptor in an Immunocompetent Mouse Model.
Festag MM, Festag J, Fräßle SP, Asen T, Sacherl J, Schreiber S, Mück-Häusl MA, Busch DH, Wisskirchen K, Protzer U.
Festag MM, et al. Among authors: sacherl j.
Mol Ther. 2019 May 8;27(5):947-959. doi: 10.1016/j.ymthe.2019.02.001. Epub 2019 Feb 10.
Mol Ther. 2019.
PMID: 30852138
Free PMC article.
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A New Role for Capsid Assembly Modulators To Target Mature Hepatitis B Virus Capsids and Prevent Virus Infection.
Ko C, Bester R, Zhou X, Xu Z, Blossey C, Sacherl J, Vondran FWR, Gao L, Protzer U.
Ko C, et al. Among authors: sacherl j.
Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01440-19. doi: 10.1128/AAC.01440-19. Print 2019 Dec 20.
Antimicrob Agents Chemother. 2019.
PMID: 31658963
Free PMC article.
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Mechanistic principles of an ultra-long bovine CDR reveal strategies for antibody design.
Svilenov HL, Sacherl J, Protzer U, Zacharias M, Buchner J.
Svilenov HL, et al. Among authors: sacherl j.
Nat Commun. 2021 Nov 18;12(1):6737. doi: 10.1038/s41467-021-27103-z.
Nat Commun. 2021.
PMID: 34795299
Free PMC article.
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Multimeric ACE2-IgM fusions as broadly active antivirals that potently neutralize SARS-CoV-2 variants.
Svilenov HL, Bester R, Sacherl J, Absmeier R, Peters C, Protzer U, Brockmeyer C, Buchner J.
Svilenov HL, et al. Among authors: sacherl j.
Commun Biol. 2022 Nov 12;5(1):1237. doi: 10.1038/s42003-022-04193-z.
Commun Biol. 2022.
PMID: 36371561
Free PMC article.
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The balanced regulation of Hsc70 by DNJ-13 and UNC-23 is required for muscle functionality.
Papsdorf K, Sacherl J, Richter K.
Papsdorf K, et al. Among authors: sacherl j.
J Biol Chem. 2014 Sep 5;289(36):25250-61. doi: 10.1074/jbc.M114.565234. Epub 2014 Jul 22.
J Biol Chem. 2014.
PMID: 25053410
Free PMC article.
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Efficient stabilization of therapeutic hepatitis B vaccine components by amino-acid formulation maintains its potential to break immune tolerance.
Sacherl J, Kosinska AD, Kemter K, Kächele M, Laumen SC, Kerth HA, Öz EA, Wolff LS, Su J, Essbauer S, Sutter G, Scholz M, Singethan K, Altrichter J, Protzer U.
Sacherl J, et al.
JHEP Rep. 2022 Oct 13;5(2):100603. doi: 10.1016/j.jhepr.2022.100603. eCollection 2023 Feb.
JHEP Rep. 2022.
PMID: 36714793
Free PMC article.
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Activation of CD4 T cells during prime immunization determines the success of a therapeutic hepatitis B vaccine in HBV-carrier mouse models.
Su J, Brunner L, Ates Oz E, Sacherl J, Frank G, Kerth HA, Thiele F, Wiegand M, Mogler C, Aguilar JC, Knolle PA, Collin N, Kosinska AD, Protzer U.
Su J, et al. Among authors: sacherl j.
J Hepatol. 2023 Apr;78(4):717-730. doi: 10.1016/j.jhep.2022.12.013. Epub 2023 Jan 9.
J Hepatol. 2023.
PMID: 36634821
Free article.
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