Mano H - Search Results

1

Development of In Vitro and In Vivo Evaluation Systems for Vitamin D Derivatives and Their Application to Drug Discovery.

Yasuda K, Nishikawa M, Mano H, Takano M, Kittaka A, Ikushiro S, Sakaki T. Yasuda K, et al. Among authors: mano h. Int J Mol Sci. 2021 Oct 31;22(21):11839. doi: 10.3390/ijms222111839. Int J Mol Sci. 2021. PMID: 34769269 Free PMC article. Review.

2

Human hepatic metabolism of the anti-osteoporosis drug eldecalcitol involves sterol C4-methyl oxidase.

Yasuda K, Iwanaga Y, Ogawa K, Mano H, Ueno S, Kimoto S, Ohta M, Kamakura M, Ikushiro S, Sakaki T. Yasuda K, et al. Among authors: mano h. Pharmacol Res Perspect. 2015 Mar;3(2):e00120. doi: 10.1002/prp2.120. Epub 2015 Feb 10. Pharmacol Res Perspect. 2015. PMID: 26038696 Free PMC article.

3

Development of Novel Bioluminescent Sensor to Detect and Discriminate between Vitamin D Receptor Agonists and Antagonists in Living Cells.

Mano H, Nishikawa M, Yasuda K, Ikushiro S, Saito N, Takano M, Kittaka A, Sakaki T. Mano H, et al. Bioconjug Chem. 2015 Oct 21;26(10):2038-45. doi: 10.1021/acs.bioconjchem.5b00433. Epub 2015 Sep 18. Bioconjug Chem. 2015. PMID: 26355700

4

Novel screening system for high-affinity ligand of heredity vitamin D-resistant rickets-associated vitamin D receptor mutant R274L using bioluminescent sensor.

Mano H, Nishikawa M, Yasuda K, Ikushiro S, Saito N, Sawada D, Honzawa S, Takano M, Kittaka A, Sakaki T. Mano H, et al. J Steroid Biochem Mol Biol. 2017 Mar;167:61-66. doi: 10.1016/j.jsbmb.2016.11.008. Epub 2016 Nov 15. J Steroid Biochem Mol Biol. 2017. PMID: 27864003

5

Production of an active form of vitamin D₂ by genetically engineered CYP105A1.

Yasuda K, Yogo Y, Sugimoto H, Mano H, Takita T, Ohta M, Kamakura M, Ikushiro S, Yasukawa K, Shiro Y, Sakaki T. Yasuda K, et al. Among authors: mano h. Biochem Biophys Res Commun. 2017 Apr 29;486(2):336-341. doi: 10.1016/j.bbrc.2017.03.040. Epub 2017 Mar 14. Biochem Biophys Res Commun. 2017. PMID: 28302483

6

Development of a highly sensitive in vitro system to detect and discriminate between vitamin D receptor agonists and antagonists based on split-luciferase technique.

Mano H, Ikushiro S, Saito N, Kittaka A, Sakaki T. Mano H, et al. J Steroid Biochem Mol Biol. 2018 Apr;178:55-59. doi: 10.1016/j.jsbmb.2017.10.024. Epub 2017 Nov 1. J Steroid Biochem Mol Biol. 2018. PMID: 29101064

7

Novel split luciferase-based biosensors for evaluation of vitamin D receptor ligands and their application to estimate CYP27B1 activity in living cells.

Mano H, Ikushiro S, Sakaki T. Mano H, et al. J Steroid Biochem Mol Biol. 2018 Oct;183:221-227. doi: 10.1016/j.jsbmb.2018.06.017. Epub 2018 Jul 9. J Steroid Biochem Mol Biol. 2018. PMID: 30004013

8

Novel biosensor using split-luciferase for detecting vitamin D receptor ligands based on the interaction between vitamin D receptor and coactivator.

Mano H, Takano M, Ikushiro S, Kittaka A, Sakaki T. Mano H, et al. Biochem Biophys Res Commun. 2018 Oct 28;505(2):460-465. doi: 10.1016/j.bbrc.2018.09.122. Epub 2018 Sep 26. Biochem Biophys Res Commun. 2018. PMID: 30268505

9

Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions.

Nishikawa M, Yasuda K, Takamatsu M, Abe K, Okamoto K, Horibe K, Mano H, Nakagawa K, Tsugawa N, Hirota Y, Horie T, Hinoi E, Okano T, Ikushiro S, Sakaki T. Nishikawa M, et al. Among authors: mano h. Sci Rep. 2020 Mar 30;10(1):5677. doi: 10.1038/s41598-020-62048-1. Sci Rep. 2020. PMID: 32231239 Free PMC article.

10

Elucidation of metabolic pathways of 25-hydroxyvitamin D3 mediated by CYP24A1 and CYP3A using Cyp24a1 knockout rats generated by CRISPR/Cas9 system.

Yasuda K, Nishikawa M, Okamoto K, Horibe K, Mano H, Yamaguchi M, Okon R, Nakagawa K, Tsugawa N, Okano T, Kawagoe F, Kittaka A, Ikushiro S, Sakaki T. Yasuda K, et al. Among authors: mano h. J Biol Chem. 2021 Jan-Jun;296:100668. doi: 10.1016/j.jbc.2021.100668. Epub 2021 Apr 15. J Biol Chem. 2021. PMID: 33865853 Free PMC article.

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