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Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents.
Cai S, Moutal A, Yu J, Chew LA, Isensee J, Chawla R, Gomez K, Luo S, Zhou Y, Chefdeville A, Madura C, Perez-Miller S, Bellampalli SS, Dorame A, Scott DD, François-Moutal L, Shan Z, Woodward T, Gokhale V, Hohmann AG, Vanderah TW, Patek M, Khanna M, Hucho T, Khanna R. Cai S, et al. Among authors: chew la. Sci Transl Med. 2021 Nov 10;13(619):eabh1314. doi: 10.1126/scitranslmed.abh1314. Epub 2021 Nov 10. Sci Transl Med. 2021. PMID: 34757807
(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology.
Moutal A, Chew LA, Yang X, Wang Y, Yeon SK, Telemi E, Meroueh S, Park KD, Shrinivasan R, Gilbraith KB, Qu C, Xie JY, Patwardhan A, Vanderah TW, Khanna M, Porreca F, Khanna R. Moutal A, et al. Among authors: chew la. Pain. 2016 Jul;157(7):1448-1463. doi: 10.1097/j.pain.0000000000000555. Pain. 2016. PMID: 26967696 Free PMC article.
Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors.
Moutal A, Wang Y, Yang X, Ji Y, Luo S, Dorame A, Bellampalli SS, Chew LA, Cai S, Dustrude ET, Keener JE, Marty MT, Vanderah TW, Khanna R. Moutal A, et al. Among authors: chew la. Pain. 2017 Nov;158(11):2203-2221. doi: 10.1097/j.pain.0000000000001026. Pain. 2017. PMID: 28767512 Free PMC article.
CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide.
Moutal A, Yang X, Li W, Gilbraith KB, Luo S, Cai S, François-Moutal L, Chew LA, Yeon SK, Bellampalli SS, Qu C, Xie JY, Ibrahim MM, Khanna M, Park KD, Porreca F, Khanna R. Moutal A, et al. Among authors: chew la. Pain. 2017 Dec;158(12):2301-2319. doi: 10.1097/j.pain.0000000000001002. Pain. 2017. PMID: 28809766 Free PMC article.
Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy.
Khanna R, Yu J, Yang X, Moutal A, Chefdeville A, Gokhale V, Shuja Z, Chew LA, Bellampalli SS, Luo S, François-Moutal L, Serafini MJ, Ha T, Perez-Miller S, Park KD, Patwardhan AM, Streicher JM, Colecraft HM, Khanna M. Khanna R, et al. Among authors: chew la. Pain. 2019 Jul;160(7):1644-1661. doi: 10.1097/j.pain.0000000000001524. Pain. 2019. PMID: 30933958 Free PMC article.
21 results