Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

6,861 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Results By Year timeline is not available.
Page 1
Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action.
Escher SE, Aguayo-Orozco A, Benfenati E, Bitsch A, Braunbeck T, Brotzmann K, Bois F, van der Burg B, Castel J, Exner T, Gadaleta D, Gardner I, Goldmann D, Hatley O, Golbamaki N, Graepel R, Jennings P, Limonciel A, Long A, Maclennan R, Mombelli E, Norinder U, Jain S, Capinha LS, Taboureau OT, Tolosa L, Vrijenhoek NG, van Vugt-Lussenburg BMA, Walker P, van de Water B, Wehr M, White A, Zdrazil B, Fisher C. Escher SE, et al. Among authors: white a. Toxicol In Vitro. 2022 Mar;79:105269. doi: 10.1016/j.tiv.2021.105269. Epub 2021 Oct 29. Toxicol In Vitro. 2022. PMID: 34757180 Free article.
Vision of a near future: Bridging the human health-environment divide. Toward an integrated strategy to understand mechanisms across species for chemical safety assessment.
Rivetti C, Allen TEH, Brown JB, Butler E, Carmichael PL, Colbourne JK, Dent M, Falciani F, Gunnarsson L, Gutsell S, Harrill JA, Hodges G, Jennings P, Judson R, Kienzler A, Margiotta-Casaluci L, Muller I, Owen SF, Rendal C, Russell PJ, Scott S, Sewell F, Shah I, Sorrel I, Viant MR, Westmoreland C, White A, Campos B. Rivetti C, et al. Among authors: white a. Toxicol In Vitro. 2020 Feb;62:104692. doi: 10.1016/j.tiv.2019.104692. Epub 2019 Oct 25. Toxicol In Vitro. 2020. PMID: 31669395 Review.
Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project.
Escher SE, Kamp H, Bennekou SH, Bitsch A, Fisher C, Graepel R, Hengstler JG, Herzler M, Knight D, Leist M, Norinder U, Ouédraogo G, Pastor M, Stuard S, White A, Zdrazil B, van de Water B, Kroese D. Escher SE, et al. Among authors: white a. Arch Toxicol. 2019 Dec;93(12):3643-3667. doi: 10.1007/s00204-019-02591-7. Epub 2019 Nov 28. Arch Toxicol. 2019. PMID: 31781791
If appropriately applied, a read-across approach can be used instead of de novo animal testing. ...New concepts, in vitro and in silico tools are needed to better characterise these properties, collectively called new approach methodologies (NAMs). This white paper …
If appropriately applied, a read-across approach can be used instead of de novo animal testing. ...New concepts, in vitro and in sili …
New approach methods (NAMs) supporting read-across: Two neurotoxicity AOP-based IATA case studies.
Van der Stel W, Carta G, Eakins J, Delp J, Suciu I, Forsby A, Cediel-Ulloa A, Attoff K, Troger F, Kamp H, Gardner I, Zdrazil B, Moné MJ, Ecker GF, Pastor M, Gómez-Tamayo JC, White A, Danen EHJ, Leist M, Walker P, Jennings P, Hougaard Bennekou S, Van de Water B. Van der Stel W, et al. Among authors: white a. ALTEX. 2021;38(4):615-635. doi: 10.14573/altex.2103051. Epub 2021 Jun 10. ALTEX. 2021. PMID: 34114044 Free article.
Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation.
van der Stel W, Yang H, Vrijenhoek NG, Schimming JP, Callegaro G, Carta G, Darici S, Delp J, Forsby A, White A, le Dévédec S, Leist M, Jennings P, Beltman JB, van de Water B, Danen EHJ. van der Stel W, et al. Among authors: white a. Arch Toxicol. 2022 Jan;96(1):259-285. doi: 10.1007/s00204-021-03160-7. Epub 2021 Oct 13. Arch Toxicol. 2022. PMID: 34642769 Free PMC article.
Beyond AOPs: A Mechanistic Evaluation of NAMs in DART Testing.
Rajagopal R, Baltazar MT, Carmichael PL, Dent MP, Head J, Li H, Muller I, Reynolds J, Sadh K, Simpson W, Spriggs S, White A, Kukic P. Rajagopal R, et al. Among authors: white a. Front Toxicol. 2022 Mar 7;4:838466. doi: 10.3389/ftox.2022.838466. eCollection 2022. Front Toxicol. 2022. PMID: 35295212 Free PMC article.
Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses.
Ter Braak B, Klip JE, Wink S, Hiemstra S, Cooper SL, Middleton A, White A, van de Water B. Ter Braak B, et al. Among authors: white a. Toxicol In Vitro. 2022 Oct;84:105419. doi: 10.1016/j.tiv.2022.105419. Epub 2022 Jun 17. Toxicol In Vitro. 2022. PMID: 35724838 Free article.
6,861 results