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A novel soluble complement receptor 1 fragment with enhanced therapeutic potential.
Wymann S, Dai Y, Nair AG, Cao H, Powers GA, Schnell A, Martin-Roussety G, Leong D, Simmonds J, Lieu KG, de Souza MJ, Mischnik M, Taylor S, Ow SY, Spycher M, Butcher RE, Pearse M, Zuercher AW, Baz Morelli A, Panousis C, Wilson MJ, Rowe T, Hardy MP. Wymann S, et al. Among authors: hardy mp. J Biol Chem. 2021 Jan-Jun;296:100200. doi: 10.1074/jbc.RA120.016127. Epub 2020 Dec 23. J Biol Chem. 2021. PMID: 33334893 Free PMC article.
Sialylation-dependent pharmacokinetics and differential complement pathway inhibition are hallmarks of CR1 activity in vivo.
Wymann S, Mischnik M, Leong D, Ghosh S, Tan X, Cao H, Kuehnemuth B, Powers GA, Halder P, de Souza MJ, James HS, Tomasetig V, Lind H, Rossato P, Owczarek CM, Ow SY, Dower SK, Baz Morelli A, Rowe T, Hardy MP. Wymann S, et al. Among authors: hardy mp. Biochem J. 2022 May 13;479(9):1007-1030. doi: 10.1042/BCJ20220054. Biochem J. 2022. PMID: 35470373
Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody.
Broughton SE, Hercus TR, Hardy MP, McClure BJ, Nero TL, Dottore M, Huynh H, Braley H, Barry EF, Kan WL, Dhagat U, Scotney P, Hartman D, Busfield SJ, Owczarek CM, Nash AD, Wilson NJ, Parker MW, Lopez AF. Broughton SE, et al. Among authors: hardy mp. Cell Rep. 2014 Jul 24;8(2):410-9. doi: 10.1016/j.celrep.2014.06.038. Epub 2014 Jul 17. Cell Rep. 2014. PMID: 25043189 Free article.
Modular Platform for the Development of Recombinant Hemoglobin Scavenger Biotherapeutics.
Buzzi RM, Owczarek CM, Akeret K, Tester A, Pereira N, Butcher R, Brügger-Verdon V, Hardy MP, Illi M, Wassmer A, Vallelian F, Humar R, Hugelshofer M, Buehler PW, Gentinetta T, Schaer DJ. Buzzi RM, et al. Among authors: hardy mp. Mol Pharm. 2021 Aug 2;18(8):3158-3170. doi: 10.1021/acs.molpharmaceut.1c00433. Epub 2021 Jul 22. Mol Pharm. 2021. PMID: 34292741 Free article.
175 results