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MMAB promotes negative feedback control of cholesterol homeostasis.
Goedeke L, Canfrán-Duque A, Rotllan N, Chaube B, Thompson BM, Lee RG, Cline GW, McDonald JG, Shulman GI, Lasunción MA, Suárez Y, Fernández-Hernando C. Goedeke L, et al. Among authors: mcdonald jg. Nat Commun. 2021 Nov 8;12(1):6448. doi: 10.1038/s41467-021-26787-7. Nat Commun. 2021. PMID: 34750386 Free PMC article.
27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth.
Wu Q, Ishikawa T, Sirianni R, Tang H, McDonald JG, Yuhanna IS, Thompson B, Girard L, Mineo C, Brekken RA, Umetani M, Euhus DM, Xie Y, Shaul PW. Wu Q, et al. Among authors: mcdonald jg. Cell Rep. 2013 Nov 14;5(3):637-45. doi: 10.1016/j.celrep.2013.10.006. Epub 2013 Nov 7. Cell Rep. 2013. PMID: 24210818 Free PMC article.
Bazedoxifene and conjugated estrogen prevent diet-induced obesity, hepatic steatosis, and type 2 diabetes in mice without impacting the reproductive tract.
Barrera J, Chambliss KL, Ahmed M, Tanigaki K, Thompson B, McDonald JG, Mineo C, Shaul PW. Barrera J, et al. Among authors: mcdonald jg. Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E345-54. doi: 10.1152/ajpendo.00653.2013. Epub 2014 Jun 17. Am J Physiol Endocrinol Metab. 2014. PMID: 24939737 Free article.
Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages.
Muse ED, Yu S, Edillor CR, Tao J, Spann NJ, Troutman TD, Seidman JS, Henke A, Roland JT, Ozeki KA, Thompson BM, McDonald JG, Bahadorani J, Tsimikas S, Grossman TR, Tremblay MS, Glass CK. Muse ED, et al. Among authors: mcdonald jg. Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4680-E4689. doi: 10.1073/pnas.1714518115. Epub 2018 Apr 9. Proc Natl Acad Sci U S A. 2018. PMID: 29632203 Free PMC article.
136 results