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Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis.
Hopkins BT, Bame E, Bajrami B, Black C, Bohnert T, Boiselle C, Burdette D, Burns JC, Delva L, Donaldson D, Grater R, Gu C, Hoemberger M, Johnson J, Kapadnis S, King K, Lulla M, Ma B, Marx I, Magee T, Meissner R, Metrick CM, Mingueneau M, Murugan P, Otipoby KL, Polack E, Poreci U, Prince R, Roach AM, Rowbottom C, Santoro JC, Schroeder P, Tang H, Tien E, Zhang F, Lyssikatos J. Hopkins BT, et al. Among authors: burdette d. J Med Chem. 2022 Jan 27;65(2):1206-1224. doi: 10.1021/acs.jmedchem.1c00926. Epub 2021 Nov 4. J Med Chem. 2022. PMID: 34734694
Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders.
Bonazzi S, Goold CP, Gray A, Thomsen NM, Nunez J, Karki RG, Gorde A, Biag JD, Malik HA, Sun Y, Liang G, Lubicka D, Salas S, Labbe-Giguere N, Keaney EP, McTighe S, Liu S, Deng L, Piizzi G, Lombardo F, Burdette D, Dodart JC, Wilson CJ, Peukert S, Curtis D, Hamann LG, Murphy LO. Bonazzi S, et al. Among authors: burdette d. J Med Chem. 2020 Feb 13;63(3):1068-1083. doi: 10.1021/acs.jmedchem.9b01398. Epub 2020 Jan 31. J Med Chem. 2020. PMID: 31955578
Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood-Brain Barrier Measured by Quantitative Targeted Proteomics.
Billington S, Salphati L, Hop CECA, Chu X, Evers R, Burdette D, Rowbottom C, Lai Y, Xiao G, Humphreys WG, Nguyen TB, Prasad B, Unadkat JD. Billington S, et al. Among authors: burdette d. Clin Pharmacol Ther. 2019 Jul;106(1):228-237. doi: 10.1002/cpt.1373. Epub 2019 Mar 18. Clin Pharmacol Ther. 2019. PMID: 30673124
Selective depletion of HBV-infected hepatocytes by class A capsid assembly modulators requires high levels of intrahepatic HBV core protein.
Kornyeyev D, Song Z, Eng S, Soulette C, Ramirez R, Tang J, Yue Q, Subramanian R, Zaboli S, Moon C, Tam J, Brodbeck J, Aggarwal A, Diehl L, Fletcher SP, Hyrina A, Holdorf MM, Burdette D. Kornyeyev D, et al. Among authors: burdette d. Antimicrob Agents Chemother. 2024 May 23:e0042024. doi: 10.1128/aac.00420-24. Online ahead of print. Antimicrob Agents Chemother. 2024. PMID: 38780261 Free article.
Improved Tensor Current Limit from ^{8}B β Decay Including New Recoil-Order Calculations.
Longfellow B, Gallant AT, Sargsyan GH, Burkey MT, Hirsh TY, Savard G, Scielzo ND, Varriano L, Brodeur M, Burdette DP, Clark JA, Lascar D, Launey KD, Mueller P, Ray D, Sharma KS, Valverde AA, Wilson GL, Yan XL. Longfellow B, et al. Among authors: burdette dp. Phys Rev Lett. 2024 Apr 5;132(14):142502. doi: 10.1103/PhysRevLett.132.142502. Phys Rev Lett. 2024. PMID: 38640383
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