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Hepatitis B virus envelope proteins can serve as therapeutic targets embedded in the host cell plasma membrane.
Zhao L, Chen F, Quitt O, Festag M, Ringelhan M, Wisskirchen K, Festag J, Yakovleva L, Sureau C, Bohne F, Aichler M, Bruss V, Shevtsov M, van de Klundert M, Momburg F, Möhl BS, Protzer U. Zhao L, et al. Among authors: bohne f. Cell Microbiol. 2021 Dec;23(12):e13399. doi: 10.1111/cmi.13399. Epub 2021 Nov 22. Cell Microbiol. 2021. PMID: 34729894
T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice.
Krebs K, Böttinger N, Huang LR, Chmielewski M, Arzberger S, Gasteiger G, Jäger C, Schmitt E, Bohne F, Aichler M, Uckert W, Abken H, Heikenwalder M, Knolle P, Protzer U. Krebs K, et al. Among authors: bohne f. Gastroenterology. 2013 Aug;145(2):456-65. doi: 10.1053/j.gastro.2013.04.047. Epub 2013 Apr 30. Gastroenterology. 2013. PMID: 23639914 Free article.
T-cell engager antibodies enable T cells to control HBV infection and to target HBsAg-positive hepatoma in mice.
Quitt O, Luo S, Meyer M, Xie Z, Golsaz-Shirazi F, Loffredo-Verde E, Festag J, Bockmann JH, Zhao L, Stadler D, Chou WM, Tedjokusumo R, Wettengel JM, Ko C, Noeßner E, Bulbuc N, Shokri F, Lüttgau S, Heikenwälder M, Bohne F, Moldenhauer G, Momburg F, Protzer U. Quitt O, et al. Among authors: bohne f. J Hepatol. 2021 Nov;75(5):1058-1071. doi: 10.1016/j.jhep.2021.06.022. Epub 2021 Jun 23. J Hepatol. 2021. PMID: 34171437
Interferon-γ and Tumor Necrosis Factor-α Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis.
Xia Y, Stadler D, Lucifora J, Reisinger F, Webb D, Hösel M, Michler T, Wisskirchen K, Cheng X, Zhang K, Chou WM, Wettengel JM, Malo A, Bohne F, Hoffmann D, Eyer F, Thimme R, Falk CS, Thasler WE, Heikenwalder M, Protzer U. Xia Y, et al. Among authors: bohne f. Gastroenterology. 2016 Jan;150(1):194-205. doi: 10.1053/j.gastro.2015.09.026. Epub 2015 Sep 28. Gastroenterology. 2016. PMID: 26416327 Free article.
Construction of a hepatitis B virus neutralizing chimeric monoclonal antibody recognizing escape mutants of the viral surface antigen (HBsAg).
Golsaz-Shirazi F, Amiri MM, Farid S, Bahadori M, Bohne F, Altstetter S, Wolff L, Kazemi T, Khoshnoodi J, Hojjat-Farsangi M, Chudy M, Jeddi-Tehrani M, Protzer U, Shokri F. Golsaz-Shirazi F, et al. Among authors: bohne f. Antiviral Res. 2017 Aug;144:153-163. doi: 10.1016/j.antiviral.2017.06.013. Epub 2017 Jun 19. Antiviral Res. 2017. PMID: 28641998
T Cells Engineered to Express a T-Cell Receptor Specific for Glypican-3 to Recognize and Kill Hepatoma Cells In Vitro and in Mice.
Dargel C, Bassani-Sternberg M, Hasreiter J, Zani F, Bockmann JH, Thiele F, Bohne F, Wisskirchen K, Wilde S, Sprinzl MF, Schendel DJ, Krackhardt AM, Uckert W, Wohlleber D, Schiemann M, Stemmer K, Heikenwälder M, Busch DH, Richter G, Mann M, Protzer U. Dargel C, et al. Among authors: bohne f. Gastroenterology. 2015 Oct;149(4):1042-52. doi: 10.1053/j.gastro.2015.05.055. Epub 2015 Jun 5. Gastroenterology. 2015. PMID: 26052074
45 results