Leeder JS - Search Results

1

The Impact of Age and Genetics on Naltrexone Biotransformation.

Stancil SL, Nolte W, Pearce RE, Staggs VS, Leeder JS. Stancil SL, et al. Among authors: leeder js. Drug Metab Dispos. 2022 Feb;50(2):168-173. doi: 10.1124/dmd.121.000646. Epub 2021 Nov 2. Drug Metab Dispos. 2022. PMID: 34728519 Free PMC article.

2

Potent inhibition of cytochrome P-450 2D6-mediated dextromethorphan O-demethylation by terbinafine.

Abdel-Rahman SM, Marcucci K, Boge T, Gotschall RR, Kearns GL, Leeder JS. Abdel-Rahman SM, et al. Among authors: leeder js. Drug Metab Dispos. 1999 Jul;27(7):770-5. Drug Metab Dispos. 1999. PMID: 10383919

3

Cytochrome P450 Involvement in the biotransformation of cisapride and racemic norcisapride in vitro: differential activity of individual human CYP3A isoforms.

Pearce RE, Gotschall RR, Kearns GL, Leeder JS. Pearce RE, et al. Among authors: leeder js. Drug Metab Dispos. 2001 Dec;29(12):1548-54. Drug Metab Dispos. 2001. PMID: 11717173

4

Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine.

Marcucci KA, Pearce RE, Crespi C, Steimel DT, Leeder JS, Gaedigk A. Marcucci KA, et al. Among authors: leeder js. Drug Metab Dispos. 2002 May;30(5):595-601. doi: 10.1124/dmd.30.5.595. Drug Metab Dispos. 2002. PMID: 11950793

5

Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.

Pearce RE, Vakkalagadda GR, Leeder JS. Pearce RE, et al. Among authors: leeder js. Drug Metab Dispos. 2002 Nov;30(11):1170-9. doi: 10.1124/dmd.30.11.1170. Drug Metab Dispos. 2002. PMID: 12386121

6

Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.

Gaedigk A, Bhathena A, Ndjountché L, Pearce RE, Abdel-Rahman SM, Alander SW, Bradford LD, Rogan PK, Leeder JS. Gaedigk A, et al. Among authors: leeder js. Pharmacogenomics J. 2005;5(3):173-82. doi: 10.1038/sj.tpj.6500305. Pharmacogenomics J. 2005. PMID: 15768052 Free PMC article.

7

Variability of CYP3A7 expression in human fetal liver.

Leeder JS, Gaedigk R, Marcucci KA, Gaedigk A, Vyhlidal CA, Schindel BP, Pearce RE. Leeder JS, et al. J Pharmacol Exp Ther. 2005 Aug;314(2):626-35. doi: 10.1124/jpet.105.086504. Epub 2005 Apr 21. J Pharmacol Exp Ther. 2005. PMID: 15845858 Free article.

8

Pathways of carbamazepine bioactivation in vitro: II. The role of human cytochrome P450 enzymes in the formation of 2-hydroxyiminostilbene.

Pearce RE, Uetrecht JP, Leeder JS. Pearce RE, et al. Among authors: leeder js. Drug Metab Dispos. 2005 Dec;33(12):1819-26. doi: 10.1124/dmd.105.004861. Epub 2005 Aug 31. Drug Metab Dispos. 2005. PMID: 16135660

9

Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.

Vyhlidal CA, Gaedigk R, Leeder JS. Vyhlidal CA, et al. Among authors: leeder js. Drug Metab Dispos. 2006 Jan;34(1):131-7. doi: 10.1124/dmd.105.005967. Epub 2005 Oct 21. Drug Metab Dispos. 2006. PMID: 16243958

10

Biotransformation of fluticasone: in vitro characterization.

Pearce RE, Leeder JS, Kearns GL. Pearce RE, et al. Among authors: leeder js. Drug Metab Dispos. 2006 Jun;34(6):1035-40. doi: 10.1124/dmd.105.009043. Epub 2006 Mar 24. Drug Metab Dispos. 2006. PMID: 16565171

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