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A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes.
Oswald F, Rodriguez P, Giaimo BD, Antonello ZA, Mira L, Mittler G, Thiel VN, Collins KJ, Tabaja N, Cizelsky W, Rothe M, Kühl SJ, Kühl M, Ferrante F, Hein K, Kovall RA, Dominguez M, Borggrefe T. Oswald F, et al. Nucleic Acids Res. 2016 Jun 2;44(10):4703-20. doi: 10.1093/nar/gkw105. Epub 2016 Feb 23. Nucleic Acids Res. 2016. PMID: 26912830 Free PMC article.
HDAC3 functions as a positive regulator in Notch signal transduction.
Ferrante F, Giaimo BD, Bartkuhn M, Zimmermann T, Close V, Mertens D, Nist A, Stiewe T, Meier-Soelch J, Kracht M, Just S, Klöble P, Oswald F, Borggrefe T. Ferrante F, et al. Among authors: oswald f. Nucleic Acids Res. 2020 Apr 17;48(7):3496-3512. doi: 10.1093/nar/gkaa088. Nucleic Acids Res. 2020. PMID: 32107550 Free PMC article.
Phospho-Site Mutations in Transcription Factor Suppressor of Hairless Impact Notch Signaling Activity During Hematopoiesis in Drosophila.
Frankenreiter L, Gahr BM, Schmid H, Zimmermann M, Deichsel S, Hoffmeister P, Turkiewicz A, Borggrefe T, Oswald F, Nagel AC. Frankenreiter L, et al. Among authors: oswald f. Front Cell Dev Biol. 2021 Apr 14;9:658820. doi: 10.3389/fcell.2021.658820. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33937259 Free PMC article.
Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics.
Ferrante F, Giaimo BD, Friedrich T, Sugino T, Mertens D, Kugler S, Gahr BM, Just S, Pan L, Bartkuhn M, Potente M, Oswald F, Borggrefe T. Ferrante F, et al. Among authors: oswald f. Cell Death Dis. 2022 Jul 12;13(7):600. doi: 10.1038/s41419-022-05052-9. Cell Death Dis. 2022. PMID: 35821235 Free PMC article.
A Drosophila Su(H) model of Adams-Oliver Syndrome reveals cofactor titration as a mechanism underlying developmental defects.
Gagliani EK, Gutzwiller LM, Kuang Y, Odaka Y, Hoffmeister P, Hauff S, Turkiewicz A, Harding-Theobald E, Dolph PJ, Borggrefe T, Oswald F, Gebelein B, Kovall RA. Gagliani EK, et al. Among authors: oswald f. PLoS Genet. 2022 Aug 11;18(8):e1010335. doi: 10.1371/journal.pgen.1010335. eCollection 2022 Aug. PLoS Genet. 2022. PMID: 35951645 Free PMC article.
281 results