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A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes.
Oswald F, Rodriguez P, Giaimo BD, Antonello ZA, Mira L, Mittler G, Thiel VN, Collins KJ, Tabaja N, Cizelsky W, Rothe M, Kühl SJ, Kühl M, Ferrante F, Hein K, Kovall RA, Dominguez M, Borggrefe T. Oswald F, et al. Among authors: kovall ra. Nucleic Acids Res. 2016 Jun 2;44(10):4703-20. doi: 10.1093/nar/gkw105. Epub 2016 Feb 23. Nucleic Acids Res. 2016. PMID: 26912830 Free PMC article.
CSL-Associated Corepressor and Coactivator Complexes.
Oswald F, Kovall RA. Oswald F, et al. Among authors: kovall ra. Adv Exp Med Biol. 2018;1066:279-295. doi: 10.1007/978-3-319-89512-3_14. Adv Exp Med Biol. 2018. PMID: 30030832 Review.
A Drosophila Su(H) model of Adams-Oliver Syndrome reveals cofactor titration as a mechanism underlying developmental defects.
Gagliani EK, Gutzwiller LM, Kuang Y, Odaka Y, Hoffmeister P, Hauff S, Turkiewicz A, Harding-Theobald E, Dolph PJ, Borggrefe T, Oswald F, Gebelein B, Kovall RA. Gagliani EK, et al. Among authors: kovall ra. PLoS Genet. 2022 Aug 11;18(8):e1010335. doi: 10.1371/journal.pgen.1010335. eCollection 2022 Aug. PLoS Genet. 2022. PMID: 35951645 Free PMC article.
Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation.
Kobia FM, Preusse K, Dai Q, Weaver N, Hass MR, Chaturvedi P, Stein SJ, Pear WS, Yuan Z, Kovall RA, Kuang Y, Eafergen N, Sprinzak D, Gebelein B, Brunskill EW, Kopan R. Kobia FM, et al. Among authors: kovall ra. PLoS Biol. 2020 Oct 5;18(10):e3000850. doi: 10.1371/journal.pbio.3000850. eCollection 2020 Oct. PLoS Biol. 2020. PMID: 33017398 Free PMC article.
51 results