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Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia.
Leukemia. 2022 Mar;36(3):637-647. doi: 10.1038/s41375-021-01455-3. Epub 2021 Oct 28.
Leukemia. 2022.
PMID: 34711926
Free PMC article.
IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models.
Gasilina A, Premnauth G, Gurjar P, Biesiada J, Hegde S, Milewski D, Ma G, Kalin TV, Merino E, Meller J, Seibel W, Cancelas JA, Vinnedge LP, Nassar NN.
Gasilina A, et al. Among authors: vinnedge lp.
PLoS One. 2020 Mar 12;15(3):e0229801. doi: 10.1371/journal.pone.0229801. eCollection 2020.
PLoS One. 2020.
PMID: 32163428
Free PMC article.
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