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Page 1
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.
Kerur N, Fukuda S, Banerjee D, Kim Y, Fu D, Apicella I, Varshney A, Yasuma R, Fowler BJ, Baghdasaryan E, Marion KM, Huang X, Yasuma T, Hirano Y, Serbulea V, Ambati M, Ambati VL, Kajiwara Y, Ambati K, Hirahara S, Bastos-Carvalho A, Ogura Y, Terasaki H, Oshika T, Kim KB, Hinton DR, Leitinger N, Cambier JC, Buxbaum JD, Kenney MC, Jazwinski SM, Nagai H, Hara I, West AP, Fitzgerald KA, Sadda SR, Gelfand BD, Ambati J. Kerur N, et al. Nat Med. 2018 Jan;24(1):50-61. doi: 10.1038/nm.4450. Epub 2017 Nov 27. Nat Med. 2018. PMID: 29176737 Free PMC article.
Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development.
Ambati J, Magagnoli J, Leung H, Wang SB, Andrews CA, Fu D, Pandey A, Sahu S, Narendran S, Hirahara S, Fukuda S, Sun J, Pandya L, Ambati M, Pereira F, Varshney A, Cummings T, Hardin JW, Edun B, Bennett CL, Ambati K, Fowler BJ, Kerur N, Röver C, Leitinger N, Werner BC, Stein JD, Sutton SS, Gelfand BD. Ambati J, et al. Among authors: kerur n. Nat Commun. 2020 Sep 23;11(1):4737. doi: 10.1038/s41467-020-18528-z. Nat Commun. 2020. PMID: 32968070 Free PMC article.
Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity.
Fukuda S, Narendran S, Varshney A, Nagasaka Y, Wang SB, Ambati K, Apicella I, Pereira F, Fowler BJ, Yasuma T, Hirahara S, Yasuma R, Huang P, Yerramothu P, Makin RD, Wang M, Baker KL, Marion KM, Huang X, Baghdasaryan E, Ambati M, Ambati VL, Banerjee D, Bonilha VL, Tolstonog GV, Held U, Ogura Y, Terasaki H, Oshika T, Bhattarai D, Kim KB, Feldman SH, Aguirre JI, Hinton DR, Kerur N, Sadda SR, Schumann GG, Gelfand BD, Ambati J. Fukuda S, et al. Among authors: kerur n. Sci Adv. 2021 Oct;7(40):eabj3658. doi: 10.1126/sciadv.abj3658. Epub 2021 Sep 29. Sci Adv. 2021. PMID: 34586848 Free PMC article.
RF/6A Chorioretinal Cells Do Not Display Key Endothelial Phenotypes.
Makin RD, Apicella I, Nagasaka Y, Kaneko H, Turner SD, Kerur N, Ambati J, Gelfand BD. Makin RD, et al. Among authors: kerur n. Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):5795-5802. doi: 10.1167/iovs.18-25215. Invest Ophthalmol Vis Sci. 2018. PMID: 30508043 Free PMC article.
Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration.
Fukuda S, Varshney A, Fowler BJ, Wang SB, Narendran S, Ambati K, Yasuma T, Magagnoli J, Leung H, Hirahara S, Nagasaka Y, Yasuma R, Apicella I, Pereira F, Makin RD, Magner E, Liu X, Sun J, Wang M, Baker K, Marion KM, Huang X, Baghdasaryan E, Ambati M, Ambati VL, Pandey A, Pandya L, Cummings T, Banerjee D, Huang P, Yerramothu P, Tolstonog GV, Held U, Erwin JA, Paquola ACM, Herdy JR, Ogura Y, Terasaki H, Oshika T, Darwish S, Singh RK, Mozaffari S, Bhattarai D, Kim KB, Hardin JW, Bennett CL, Hinton DR, Hanson TE, Röver C, Parang K, Kerur N, Liu J, Werner BC, Sutton SS, Sadda SR, Schumann GG, Gelfand BD, Gage FH, Ambati J. Fukuda S, et al. Among authors: kerur n. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2022751118. doi: 10.1073/pnas.2022751118. Proc Natl Acad Sci U S A. 2021. PMID: 33526699 Free PMC article.
DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs.
Wang SB, Narendran S, Hirahara S, Varshney A, Pereira F, Apicella I, Ambati M, Ambati VL, Yerramothu P, Ambati K, Nagasaka Y, Argyle D, Huang P, Baker KL, Marion KM, Gupta K, Liu B, Hinton DR, Canna SW, Sallam T, Sadda SR, Kerur N, Gelfand BD, Ambati J. Wang SB, et al. Among authors: kerur n. Sci Immunol. 2021 Dec 3;6(66):eabi4493. doi: 10.1126/sciimmunol.abi4493. Epub 2021 Dec 3. Sci Immunol. 2021. PMID: 34860583 Free PMC article.
IL-18 is not therapeutic for neovascular age-related macular degeneration.
Hirano Y, Yasuma T, Mizutani T, Fowler BJ, Tarallo V, Yasuma R, Kim Y, Bastos-Carvalho A, Kerur N, Gelfand BD, Bogdanovich S, He S, Zhang X, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Nagai H, Haro I, Núñez G, Ambati BK, Hinton DR, Ambati J. Hirano Y, et al. Among authors: kerur n. Nat Med. 2014 Dec;20(12):1372-5. doi: 10.1038/nm.3671. Nat Med. 2014. PMID: 25473914 Free PMC article. No abstract available.
Chronic Dicer1 deficiency promotes atrophic and neovascular outer retinal pathologies in mice.
Wright CB, Uehara H, Kim Y, Yasuma T, Yasuma R, Hirahara S, Makin RD, Apicella I, Pereira F, Nagasaka Y, Narendran S, Fukuda S, Albuquerque R, Fowler BJ, Bastos-Carvalho A, Georgel P, Hatada I, Chang B, Kerur N, Ambati BK, Ambati J, Gelfand BD. Wright CB, et al. Among authors: kerur n. Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2579-2587. doi: 10.1073/pnas.1909761117. Epub 2020 Jan 21. Proc Natl Acad Sci U S A. 2020. PMID: 31964819 Free PMC article.
31 results