Nichols DA - Search Results

1

Mutation of the conserved Asp-Asp pair impairs the structure, function, and inhibition of CTX-M Class A β-lactamase.

Kemp MT, Nichols DA, Zhang X, Defrees K, Na I, Renslo AR, Chen Y. Kemp MT, et al. Among authors: nichols da. FEBS Lett. 2021 Dec;595(24):2981-2994. doi: 10.1002/1873-3468.14215. Epub 2021 Nov 7. FEBS Lett. 2021. PMID: 34704263 Free PMC article.

2

Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase.

Nichols DA, Jaishankar P, Larson W, Smith E, Liu G, Beyrouthy R, Bonnet R, Renslo AR, Chen Y. Nichols DA, et al. J Med Chem. 2012 Mar 8;55(5):2163-72. doi: 10.1021/jm2014138. Epub 2012 Feb 14. J Med Chem. 2012. PMID: 22296601

3

Fragment-based inhibitor discovery against β-lactamase.

Nichols DA, Renslo AR, Chen Y. Nichols DA, et al. Future Med Chem. 2014 Mar;6(4):413-27. doi: 10.4155/fmc.14.10. Future Med Chem. 2014. PMID: 24635522 Free PMC article. Review.

4

Ligand-Induced Proton Transfer and Low-Barrier Hydrogen Bond Revealed by X-ray Crystallography.

Nichols DA, Hargis JC, Sanishvili R, Jaishankar P, Defrees K, Smith EW, Wang KK, Prati F, Renslo AR, Woodcock HL, Chen Y. Nichols DA, et al. J Am Chem Soc. 2015 Jul 1;137(25):8086-95. doi: 10.1021/jacs.5b00749. Epub 2015 Jun 22. J Am Chem Soc. 2015. PMID: 26057252 Free PMC article.

5

Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine β-Lactamases.

Pemberton OA, Zhang X, Nichols DA, DeFrees K, Jaishankar P, Bonnet R, Adams J, Shaw LN, Renslo AR, Chen Y. Pemberton OA, et al. Among authors: nichols da. Antimicrob Agents Chemother. 2018 Jul 27;62(8):e02563-17. doi: 10.1128/AAC.02563-17. Print 2018 Aug. Antimicrob Agents Chemother. 2018. PMID: 29844038 Free PMC article.

6

Structural and Mechanistic Analysis of Drosophila melanogaster Agmatine N-Acetyltransferase, an Enzyme that Catalyzes the Formation of N-Acetylagmatine.

Dempsey DR, Nichols DA, Battistini MR, Pemberton O, Ospina SR, Zhang X, Carpenter AM, O'Flynn BG, Leahy JW, Kanwar A, Lewandowski EM, Chen Y, Merkler DJ. Dempsey DR, et al. Among authors: nichols da. Sci Rep. 2017 Oct 18;7(1):13432. doi: 10.1038/s41598-017-13669-6. Sci Rep. 2017. PMID: 29044148 Free PMC article.

7

Automated Apnea-Hypopnea Index from Oximetry and Spectral Analysis of Cardiopulmonary Coupling.

Al Ashry HS, Hilmisson H, Ni Y, Thomas RJ; APPLES Investigators. Al Ashry HS, et al. Ann Am Thorac Soc. 2021 May;18(5):876-883. doi: 10.1513/AnnalsATS.202005-510OC. Ann Am Thorac Soc. 2021. PMID: 33472017

8

Objective adherence to dental device versus positive airway pressure treatment in adults with obstructive sleep apnea.

Xu L, Xie D, Griffin KS, Staley B, Wang Y, Nichols DA, Benca RM, Pack AI, Redline S, Walsh JK, Kushida CA, Kuna ST. Xu L, et al. Among authors: nichols da. J Sleep Res. 2021 Aug;30(4):e13240. doi: 10.1111/jsr.13240. Epub 2020 Nov 30. J Sleep Res. 2021. PMID: 33258284 Clinical Trial.

9

Correction to: Design and validation of an osteochondral bioreactor for the screening of treatments for osteoarthritis.

Nichols DA, Sondh IS, Little SR, Zunino P, Gottardi R. Nichols DA, et al. Biomed Microdevices. 2018 May 8;20(2):39. doi: 10.1007/s10544-018-0283-7. Biomed Microdevices. 2018. PMID: 29736756 Free PMC article.

10

Design and validation of an osteochondral bioreactor for the screening of treatments for osteoarthritis.

Nichols DA, Sondh IS, Little SR, Zunino P, Gottardi R. Nichols DA, et al. Biomed Microdevices. 2018 Feb 14;20(1):18. doi: 10.1007/s10544-018-0264-x. Biomed Microdevices. 2018. PMID: 29445972 Free PMC article.

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