Chen P - Search Results

1

Cas12a variants designed for lower genome-wide off-target effect through stringent PAM recognition.

Zhou J, Chen P, Wang H, Liu H, Li Y, Zhang Y, Wu Y, Paek C, Sun Z, Lei J, Yin L. Zhou J, et al. Among authors: chen p. Mol Ther. 2022 Jan 5;30(1):244-255. doi: 10.1016/j.ymthe.2021.10.010. Epub 2021 Oct 20. Mol Ther. 2022. PMID: 34687846 Free PMC article.

2

Substrate analog interaction with MCR-1 offers insight into the rising threat of the plasmid-mediated transferable colistin resistance.

Wei P, Song G, Shi M, Zhou Y, Liu Y, Lei J, Chen P, Yin L. Wei P, et al. Among authors: chen p. FASEB J. 2018 Feb;32(2):1085-1098. doi: 10.1096/fj.201700705R. Epub 2018 Jan 3. FASEB J. 2018. PMID: 29079699

These data demonstrate the crucial role of the PEA- and lipid A-binding pockets and provide novel insights into the structure-based mechanisms, important drug-target hot spots, and a drug template for further drug development to combat the urgent, rising threat of MCR-1-mediated …

These data demonstrate the crucial role of the PEA- and lipid A-binding pockets and provide novel insights into the structure-based mechanis …

3

A Cas12a ortholog with stringent PAM recognition followed by low off-target editing rates for genome editing.

Chen P, Zhou J, Wan Y, Liu H, Li Y, Liu Z, Wang H, Lei J, Zhao K, Zhang Y, Wang Y, Zhang X, Yin L. Chen P, et al. Genome Biol. 2020 Mar 25;21(1):78. doi: 10.1186/s13059-020-01989-2. Genome Biol. 2020. PMID: 32213191 Free PMC article.

4

Activating receptor KIR2DS2 bound to HLA-C1 reveals the novel recognition features of activating receptor.

Yang Y, Bai H, Wu Y, Chen P, Zhou J, Lei J, Ye X, Brown AJ, Zhou X, Shu T, Chen Y, Wei P, Yin L. Yang Y, et al. Among authors: chen p, chen y. Immunology. 2022 Mar;165(3):341-354. doi: 10.1111/imm.13439. Epub 2022 Jan 11. Immunology. 2022. PMID: 34967442 Free article.

5

Structural basis of the TCR-pHLA complex provides insights into the unconventional recognition of CDR3β in TCR cross-reactivity and alloreactivity.

San D, Lei J, Liu Y, Jing B, Ye X, Wei P, Paek C, Yang Y, Zhou J, Chen P, Wang H, Chen Y, Yin L. San D, et al. Among authors: chen p, chen y. Cell Insight. 2022 Dec 29;2(1):100076. doi: 10.1016/j.cellin.2022.100076. eCollection 2023 Feb. Cell Insight. 2022. PMID: 37192909 Free PMC article.

6

C2c1-sgRNA Complex Structure Reveals RNA-Guided DNA Cleavage Mechanism.

Liu L, Chen P, Wang M, Li X, Wang J, Yin M, Wang Y. Liu L, et al. Among authors: chen p. Mol Cell. 2017 Jan 19;65(2):310-322. doi: 10.1016/j.molcel.2016.11.040. Epub 2016 Dec 15. Mol Cell. 2017. PMID: 27989439 Free article.

7

Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities.

Liu L, Li X, Wang J, Wang M, Chen P, Yin M, Li J, Sheng G, Wang Y. Liu L, et al. Among authors: chen p. Cell. 2017 Jan 12;168(1-2):121-134.e12. doi: 10.1016/j.cell.2016.12.031. Epub 2017 Jan 12. Cell. 2017. PMID: 28086085 Free article.

8

ER-localized Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection.

Lu Y, Qiu Y, Chen P, Chang H, Guo L, Zhang F, Ma L, Zhang C, Zheng X, Xiao J, Zhong R, Han L, Xu X, Zhang Y, Li D, Zhong G, Boyton R, Huang Y, He Y, Hu R, Wei B, Wang H. Lu Y, et al. Among authors: chen p. Nat Microbiol. 2019 Dec;4(12):2331-2346. doi: 10.1038/s41564-019-0542-2. Nat Microbiol. 2019. PMID: 31477895 Free article.

9

An Integrative Synthetic Biology Approach to Interrogating Cellular Ubiquitin and Ufm Signaling.

Li C, Han T, Guo R, Chen P, Peng C, Prag G, Hu R. Li C, et al. Among authors: chen p. Int J Mol Sci. 2020 Jun 14;21(12):4231. doi: 10.3390/ijms21124231. Int J Mol Sci. 2020. PMID: 32545848 Free PMC article.

10

Mammalian IRE1α dynamically and functionally coalesces with stress granules.

Liu S, Zhang X, Yao X, Wang G, Huang S, Chen P, Tang M, Cai J, Wu Z, Zhang Y, Xu R, Liu K, He K, Wang Y, Jiang L, Wang QA, Rui L, Liu J, Liu Y. Liu S, et al. Among authors: chen p. Nat Cell Biol. 2024 May 7. doi: 10.1038/s41556-024-01418-7. Online ahead of print. Nat Cell Biol. 2024. PMID: 38714852

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

27,473 results

Search Page