Prasad C - Search Results

1

Discovery of Dolastatinol: A Synthetic Analog of Dolastatin 10 and Low Nanomolar Inhibitor of Tubulin Polymerization.

Gutman H, Bazylevich A, Prasad C, Dorfman O, Hesin A, Marks V, Patsenker L, Gellerman G. Gutman H, et al. Among authors: prasad c. ACS Med Chem Lett. 2021 Sep 7;12(10):1596-1604. doi: 10.1021/acsmedchemlett.1c00432. eCollection 2021 Oct 14. ACS Med Chem Lett. 2021. PMID: 34676042 Free PMC article.

2

Targeted methylation facilitates DNA double strand breaks and enhances cancer suppression: A DNA intercalating/methylating dual-action chimera Amonafidazene.

Walunj D, Thankarajan E, Prasad C, Tuchinsky H, Baldan S, Sherman MY, Patsenker L, Gellerman G. Walunj D, et al. Among authors: prasad c. Eur J Med Chem. 2021 Dec 5;225:113811. doi: 10.1016/j.ejmech.2021.113811. Epub 2021 Aug 31. Eur J Med Chem. 2021. PMID: 34507011

3

A novel, dual action chimera comprising DNA methylating agent and near-IR xanthene-cyanine photosensitizer for combined anticancer therapy.

Thankarajan E, Walunj D, Bazylevich A, Prasad C, Hesin A, Patsenker L, Gellerman G. Thankarajan E, et al. Among authors: prasad c. Photodiagnosis Photodyn Ther. 2022 Mar;37:102722. doi: 10.1016/j.pdpdt.2022.102722. Epub 2022 Jan 13. Photodiagnosis Photodyn Ther. 2022. PMID: 35032703

4

Synthesis and biological evaluation of theranostic Trastuzumab-SN38 conjugate for Near-IR fluorescence imaging and targeted therapy of HER2+ breast cancer.

Kobzev D, Prasad C, Walunj D, Gotman H, Semenova O, Bazylevich A, Patsenker L, Gellerman G. Kobzev D, et al. Among authors: prasad c. Eur J Med Chem. 2023 Apr 5;252:115298. doi: 10.1016/j.ejmech.2023.115298. Epub 2023 Mar 22. Eur J Med Chem. 2023. PMID: 36966651

5

Aspartyl alpha-((1-phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl ketones as interleukin-1 beta converting enzyme inhibitors. Significance of the P1 and P3 amido nitrogens for enzyme-peptide inhibitor binding.

Dolle RE, Singh J, Rinker J, Hoyer D, Prasad CV, Graybill TL, Salvino JM, Helaszek CT, Miller RE, Ator MA. Dolle RE, et al. Among authors: prasad cv. J Med Chem. 1994 Nov 11;37(23):3863-6. doi: 10.1021/jm00049a001. J Med Chem. 1994. PMID: 7966144 No abstract available.

6

First examples of peptidomimetic inhibitors of interleukin-1 beta converting enzyme.

Dolle RE, Prouty CP, Prasad CV, Cook E, Saha A, Ross TM, Salvino JM, Helaszek CT, Ator MA. Dolle RE, et al. Among authors: prasad cv. J Med Chem. 1996 Jun 21;39(13):2438-40. doi: 10.1021/jm9601516. J Med Chem. 1996. PMID: 8691439 No abstract available.

7

P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta-converting enzyme.

Dolle RE, Hoyer D, Prasad CV, Schmidt SJ, Helaszek CT, Miller RE, Ator MA. Dolle RE, et al. Among authors: prasad cv. J Med Chem. 1994 Mar 4;37(5):563-4. doi: 10.1021/jm00031a003. J Med Chem. 1994. PMID: 8126694 No abstract available.

8

2,3-Benzodiazepin-1,4-diones as peptidomimetic inhibitors of gamma-secretase.

Prasad CV, Vig S, Smith DW, Gao Q, Polson CT, Corsa JA, Guss VL, Loo A, Barten DM, Zheng M, Felsenstein KM, Roberts SB. Prasad CV, et al. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3535-8. doi: 10.1016/j.bmcl.2004.04.056. Bioorg Med Chem Lett. 2004. PMID: 15177468

9

Pyridazinodiazepines as a high-affinity, P2-P3 peptidomimetic class of interleukin-1 beta-converting enzyme inhibitor.

Dolle RE, Prasad CV, Prouty CP, Salvino JM, Awad MM, Schmidt SJ, Hoyer D, Ross TM, Graybill TL, Speier GJ, Uhl J, Miller BE, Helaszek CT, Ator MA. Dolle RE, et al. Among authors: prasad cv. J Med Chem. 1997 Jun 20;40(13):1941-6. doi: 10.1021/jm9701637. J Med Chem. 1997. PMID: 9207934 No abstract available.

10

Hydroxytriamides as potent gamma-secretase inhibitors.

Prasad CV, Wallace OB, Noonan JW, Sloan CP, Lau W, Vig S, Parker MF, Smith DW, Hansel SB, Polson CT, Barten DM, Felsenstein KM, Roberts SB. Prasad CV, et al. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1917-21. doi: 10.1016/j.bmcl.2004.01.086. Bioorg Med Chem Lett. 2004. PMID: 15050627

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