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An alphavirus replicon-based vaccine expressing a stabilized Spike antigen induces protective immunity and prevents transmission of SARS-CoV-2 between cats.
Langereis MA, Albulescu IC, Stammen-Vogelzangs J, Lambregts M, Stachura K, Miller S, Bosco-Lauth AM, Hartwig AE, Porter SM, Allen M, Mogler M, van Kuppeveld FJM, Bosch BJ, Vermeij P, de Groof A, Bowen RA, Davis R, Xu Z, Tarpey I. Langereis MA, et al. Among authors: van kuppeveld fjm. NPJ Vaccines. 2021 Oct 20;6(1):122. doi: 10.1038/s41541-021-00390-9. NPJ Vaccines. 2021. PMID: 34671047 Free PMC article.
Modification of picornavirus genomic RNA using 'click' chemistry shows that unlinking of the VPg peptide is dispensable for translation and replication of the incoming viral RNA.
Langereis MA, Feng Q, Nelissen FH, Virgen-Slane R, van der Heden van Noort GJ, Maciejewski S, Filippov DV, Semler BL, van Delft FL, van Kuppeveld FJ. Langereis MA, et al. Nucleic Acids Res. 2014 Feb;42(4):2473-82. doi: 10.1093/nar/gkt1162. Epub 2013 Nov 15. Nucleic Acids Res. 2014. PMID: 24243841 Free PMC article.
Enterovirus 2Apro targets MDA5 and MAVS in infected cells.
Feng Q, Langereis MA, Lork M, Nguyen M, Hato SV, Lanke K, Emdad L, Bhoopathi P, Fisher PB, Lloyd RE, van Kuppeveld FJ. Feng Q, et al. J Virol. 2014 Mar;88(6):3369-78. doi: 10.1128/JVI.02712-13. Epub 2014 Jan 3. J Virol. 2014. PMID: 24390337 Free PMC article.
260 results