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Exploration of the 2,3-dihydroisoindole pharmacophore for inhibition of the influenza virus PA endonuclease.
Bioorg Chem. 2021 Nov;116:105388. doi: 10.1016/j.bioorg.2021.105388. Epub 2021 Oct 1.
Bioorg Chem. 2021.
PMID: 34670331
Free PMC article.
A broad influenza virus inhibitor acting via IMP dehydrogenase and in synergism with ribavirin.
Vanderlinden E, Marchand A, Van Berwaer R, van Dam W, Arzel P, Klaassen H, Persoons L, Chaltin P, Naesens L.
Vanderlinden E, et al. Among authors: van berwaer r.
Antiviral Res. 2021 Dec;196:105208. doi: 10.1016/j.antiviral.2021.105208. Epub 2021 Nov 16.
Antiviral Res. 2021.
PMID: 34793841
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Cell line-dependent activation and antiviral activity of T-1105, the non-fluorinated analogue of T-705 (favipiravir).
Huchting J, Vanderlinden E, Van Berwaer R, Meier C, Naesens L.
Huchting J, et al. Among authors: van berwaer r.
Antiviral Res. 2019 Jul;167:1-5. doi: 10.1016/j.antiviral.2019.04.002. Epub 2019 Apr 2.
Antiviral Res. 2019.
PMID: 30951731
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Impact of SARS-CoV-2 Spike Mutations on Its Activation by TMPRSS2 and the Alternative TMPRSS13 Protease.
Stevaert A, Van Berwaer R, Mestdagh C, Vandeput J, Vanstreels E, Raeymaekers V, Laporte M, Naesens L.
Stevaert A, et al. Among authors: van berwaer r.
mBio. 2022 Aug 30;13(4):e0137622. doi: 10.1128/mbio.01376-22. Epub 2022 Aug 1.
mBio. 2022.
PMID: 35913162
Free PMC article.
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Favipiravir Does Not Inhibit Chikungunya Virus Replication in Mosquito Cells and Aedes aegypti Mosquitoes.
Jacobs S, Wang L, Rosales Rosas AL, Van Berwaer R, Vanderlinden E, Failloux AB, Naesens L, Delang L.
Jacobs S, et al. Among authors: van berwaer r.
Microorganisms. 2021 Apr 27;9(5):944. doi: 10.3390/microorganisms9050944.
Microorganisms. 2021.
PMID: 33925738
Free PMC article.
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The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airways.
Laporte M, Raeymaekers V, Van Berwaer R, Vandeput J, Marchand-Casas I, Thibaut HJ, Van Looveren D, Martens K, Hoffmann M, Maes P, Pöhlmann S, Naesens L, Stevaert A.
Laporte M, et al. Among authors: van berwaer r.
PLoS Pathog. 2021 Apr 22;17(4):e1009500. doi: 10.1371/journal.ppat.1009500. eCollection 2021 Apr.
PLoS Pathog. 2021.
PMID: 33886690
Free PMC article.
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