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Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine's rewarding effects but preserves natural reward processing.
Andrianarivelo A, Saint-Jour E, Pousinha P, Fernandez SP, Petitbon A, De Smedt-Peyrusse V, Heck N, Ortiz V, Allichon MC, Kappès V, Betuing S, Walle R, Zhu Y, Joséphine C, Bemelmans AP, Turecki G, Mechawar N, Javitch JA, Caboche J, Trifilieff P, Barik J, Vanhoutte P. Andrianarivelo A, et al. Among authors: heck n. Sci Adv. 2021 Oct 22;7(43):eabg5970. doi: 10.1126/sciadv.abg5970. Epub 2021 Oct 20. Sci Adv. 2021. PMID: 34669474 Free PMC article.
Rapid Synaptogenesis in the Nucleus Accumbens Is Induced by a Single Cocaine Administration and Stabilized by Mitogen-Activated Protein Kinase Interacting Kinase-1 Activity.
Dos Santos M, Salery M, Forget B, Garcia Perez MA, Betuing S, Boudier T, Vanhoutte P, Caboche J, Heck N. Dos Santos M, et al. Among authors: heck n. Biol Psychiatry. 2017 Dec 1;82(11):806-818. doi: 10.1016/j.biopsych.2017.03.014. Epub 2017 Mar 29. Biol Psychiatry. 2017. PMID: 28545678 Free article.
Cocaine increases dopaminergic connectivity in the nucleus accumbens.
Dos Santos M, Cahill EN, Bo GD, Vanhoutte P, Caboche J, Giros B, Heck N. Dos Santos M, et al. Among authors: heck n. Brain Struct Funct. 2018 Mar;223(2):913-923. doi: 10.1007/s00429-017-1532-x. Epub 2017 Oct 12. Brain Struct Funct. 2018. PMID: 29027032
Npas4 regulates medium spiny neuron physiology and gates cocaine-induced hyperlocomotion.
Lissek T, Andrianarivelo A, Saint-Jour E, Allichon MC, Bauersachs HG, Nassar M, Piette C, Pruunsild P, Tan YW, Forget B, Heck N, Caboche J, Venance L, Vanhoutte P, Bading H. Lissek T, et al. Among authors: heck n. EMBO Rep. 2021 Dec 6;22(12):e51882. doi: 10.15252/embr.202051882. Epub 2021 Oct 18. EMBO Rep. 2021. PMID: 34661342 Free PMC article.
73 results