Harki DA - Search Results

1

A Chemical Strategy for Intracellular Arming of an Endogenous Broad-Spectrum Antiviral Nucleotide.

Passow KT, Caldwell HS, Ngo KA, Arnold JJ, Antczak NM, Narayanan A, Jose J, Sturla SJ, Cameron CE, Ciota AT, Harki DA. Passow KT, et al. Among authors: harki da. J Med Chem. 2021 Oct 28;64(20):15429-15439. doi: 10.1021/acs.jmedchem.1c01481. Epub 2021 Oct 18. J Med Chem. 2021. PMID: 34661397 Free PMC article.

2

Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole.

Harki DA, Graci JD, Korneeva VS, Ghosh SK, Hong Z, Cameron CE, Peterson BR. Harki DA, et al. Biochemistry. 2002 Jul 23;41(29):9026-33. doi: 10.1021/bi026120w. Biochemistry. 2002. PMID: 12119016

3

Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases.

Harki DA, Graci JD, Galarraga JE, Chain WJ, Cameron CE, Peterson BR. Harki DA, et al. J Med Chem. 2006 Oct 19;49(21):6166-9. doi: 10.1021/jm060872x. J Med Chem. 2006. PMID: 17034123 Free PMC article.

4

Synthesis of a universal 5-nitroindole ribonucleotide and incorporation into RNA by a viral RNA-dependent RNA polymerase.

Harki DA, Graci JD, Edathil JP, Castro C, Cameron CE, Peterson BR. Harki DA, et al. Chembiochem. 2007 Aug 13;8(12):1359-62. doi: 10.1002/cbic.200700160. Chembiochem. 2007. PMID: 17600792 Free PMC article. No abstract available.

5

Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue.

Graci JD, Harki DA, Korneeva VS, Edathil JP, Too K, Franco D, Smidansky ED, Paul AV, Peterson BR, Brown DM, Loakes D, Cameron CE. Graci JD, et al. Among authors: harki da. J Virol. 2007 Oct;81(20):11256-66. doi: 10.1128/JVI.01028-07. Epub 2007 Aug 8. J Virol. 2007. PMID: 17686844 Free PMC article.

6

Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues.

Graci JD, Too K, Smidansky ED, Edathil JP, Barr EW, Harki DA, Galarraga JE, Bollinger JM Jr, Peterson BR, Loakes D, Brown DM, Cameron CE. Graci JD, et al. Among authors: harki da. Antimicrob Agents Chemother. 2008 Mar;52(3):971-9. doi: 10.1128/AAC.01056-07. Epub 2008 Jan 7. Antimicrob Agents Chemother. 2008. PMID: 18180344 Free PMC article.

7

Oxidative Reactivities of 2-Furylquinolines: Ubiquitous Scaffolds in Common High-Throughput Screening Libraries.

Olson ME, Abate-Pella D, Perkins AL, Li M, Carpenter MA, Rathore A, Harris RS, Harki DA. Olson ME, et al. Among authors: harki da. J Med Chem. 2015 Sep 24;58(18):7419-30. doi: 10.1021/acs.jmedchem.5b00930. Epub 2015 Sep 11. J Med Chem. 2015. PMID: 26358009 Free PMC article.

8

Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions.

Jackson PA, Widen JC, Harki DA, Brummond KM. Jackson PA, et al. Among authors: harki da. J Med Chem. 2017 Feb 9;60(3):839-885. doi: 10.1021/acs.jmedchem.6b00788. Epub 2016 Dec 20. J Med Chem. 2017. PMID: 27996267 Free PMC article.

9

Signatures of Nucleotide Analog Incorporation by an RNA-Dependent RNA Polymerase Revealed Using High-Throughput Magnetic Tweezers.

Dulin D, Arnold JJ, van Laar T, Oh HS, Lee C, Perkins AL, Harki DA, Depken M, Cameron CE, Dekker NH. Dulin D, et al. Among authors: harki da. Cell Rep. 2017 Oct 24;21(4):1063-1076. doi: 10.1016/j.celrep.2017.10.005. Cell Rep. 2017. PMID: 29069588 Free PMC article.

10

4-Cyanoindole-2'-deoxyribonucleoside (4CIN): A Universal Fluorescent Nucleoside Analogue.

Passow KT, Harki DA. Passow KT, et al. Among authors: harki da. Org Lett. 2018 Jul 20;20(14):4310-4313. doi: 10.1021/acs.orglett.8b01746. Epub 2018 Jul 10. Org Lett. 2018. PMID: 29989830 Free PMC article.

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