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Panobinostat Effectively Increases Histone Acetylation and Alters Chromatin Accessibility Landscape in Canine Embryonic Fibroblasts but Does Not Enhance Cellular Reprogramming.
Front Vet Sci. 2021 Sep 29;8:716570. doi: 10.3389/fvets.2021.716570. eCollection 2021.
Front Vet Sci. 2021.
PMID: 34660761
Free PMC article.
IDH1 mutant glioma is preferentially sensitive to the HDAC inhibitor panobinostat.
Sears TK, Horbinski CM, Woolard KD.
Sears TK, et al.
J Neurooncol. 2021 Sep;154(2):159-170. doi: 10.1007/s11060-021-03829-0. Epub 2021 Aug 23.
J Neurooncol. 2021.
PMID: 34424450
Free PMC article.
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Repurposing FDA approved drugs inhibiting mitochondrial function for targeting glioma-stem like cells.
Datta S, Sears T, Cortopassi G, Woolard K, Angelastro JM.
Datta S, et al.
Biomed Pharmacother. 2021 Jan;133:111058. doi: 10.1016/j.biopha.2020.111058. Epub 2020 Dec 8.
Biomed Pharmacother. 2021.
PMID: 33378970
Free PMC article.
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R132H IDH1 sensitizes glioma to the antiproliferative and cytotoxic effects of BET inhibition.
Sears TK, Woolard KD.
Sears TK, et al.
J Cancer Res Clin Oncol. 2022 Sep;148(9):2275-2285. doi: 10.1007/s00432-022-04018-w. Epub 2022 Apr 25.
J Cancer Res Clin Oncol. 2022.
PMID: 35467128
Free PMC article.
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Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer.
Allen SA, Datta S, Sandoval J, Tomilov A, Sears T, Woolard K, Angelastro JM, Cortopassi GA.
Allen SA, et al.
Mitochondrion. 2020 Jan;50:19-24. doi: 10.1016/j.mito.2019.09.009. Epub 2019 Oct 22.
Mitochondrion. 2020.
PMID: 31654752
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Novel mTORC1 Inhibitors Kill Glioblastoma Stem Cells.
Sandoval JA, Tomilov A, Datta S, Allen S, O'Donnell R, Sears T, Woolard K, Kovalskyy D, Angelastro JM, Cortopassi G.
Sandoval JA, et al.
Pharmaceuticals (Basel). 2020 Nov 24;13(12):419. doi: 10.3390/ph13120419.
Pharmaceuticals (Basel). 2020.
PMID: 33255358
Free PMC article.
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The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer.
Sears TK, Angelastro JM.
Sears TK, et al.
Oncotarget. 2017 Sep 20;8(48):84595-84609. doi: 10.18632/oncotarget.21102. eCollection 2017 Oct 13.
Oncotarget. 2017.
PMID: 29137451
Free PMC article.
Review.
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Postoperative risk of IDH-mutant glioma-associated seizures and their potential management with IDH-mutant inhibitors.
Drumm MR, Wang W, Sears TK, Bell-Burdett K, Javier R, Cotton KY, Webb B, Byrne K, Unruh D, Thirunavu V, Walshon J, Steffens A, McCortney K, Lukas RV, Phillips JJ, Mohamed E, Finan JD, Santana-Santos L, Heimberger AB, Franz CK, Kurz J, Templer JW, Swanson GT, Horbinski C.
Drumm MR, et al. Among authors: sears tk.
J Clin Invest. 2023 Jun 15;133(12):e168035. doi: 10.1172/JCI168035.
J Clin Invest. 2023.
PMID: 37104042
Free PMC article.
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