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Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability.
Xu S, Sun L, Dick A, Zalloum WA, Huang T, Meuser ME, Zhang X, Tao Y, Cherukupalli S, Ding D, Ding X, Gao S, Jiang X, Kang D, De Clercq E, Pannecouque C, Cocklin S, Liu X, Zhan P. Xu S, et al. Among authors: cocklin s. Eur J Med Chem. 2022 Jan 5;227:113903. doi: 10.1016/j.ejmech.2021.113903. Epub 2021 Oct 9. Eur J Med Chem. 2022. PMID: 34653770 Free PMC article.
Structural determinants for affinity enhancement of a dual antagonist peptide entry inhibitor of human immunodeficiency virus type-1.
Gopi H, Umashankara M, Pirrone V, LaLonde J, Madani N, Tuzer F, Baxter S, Zentner I, Cocklin S, Jawanda N, Miller SR, Schön A, Klein JC, Freire E, Krebs FC, Smith AB, Sodroski J, Chaiken I. Gopi H, et al. Among authors: cocklin s. J Med Chem. 2008 May 8;51(9):2638-47. doi: 10.1021/jm070814r. Epub 2008 Apr 11. J Med Chem. 2008. PMID: 18402432 Free PMC article.
Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid.
Kortagere S, Madani N, Mankowski MK, Schön A, Zentner I, Swaminathan G, Princiotto A, Anthony K, Oza A, Sierra LJ, Passic SR, Wang X, Jones DM, Stavale E, Krebs FC, Martín-García J, Freire E, Ptak RG, Sodroski J, Cocklin S, Smith AB 3rd. Kortagere S, et al. Among authors: cocklin s. J Virol. 2012 Aug;86(16):8472-81. doi: 10.1128/JVI.05006-11. Epub 2012 May 30. J Virol. 2012. PMID: 22647699 Free PMC article.
Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein.
Zentner I, Sierra LJ, Maciunas L, Vinnik A, Fedichev P, Mankowski MK, Ptak RG, Martín-García J, Cocklin S. Zentner I, et al. Among authors: cocklin s. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1132-5. doi: 10.1016/j.bmcl.2012.11.041. Epub 2012 Nov 29. Bioorg Med Chem Lett. 2013. PMID: 23305922 Free PMC article.
83 results