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New Pyrimidine and Pyridine Derivatives as Multitarget Cholinesterase Inhibitors: Design, Synthesis, and In Vitro and In Cellulo Evaluation.
Bortolami M, Pandolfi F, Tudino V, Messore A, Madia VN, De Vita D, Di Santo R, Costi R, Romeo I, Alcaro S, Colone M, Stringaro A, Espargaró A, Sabatè R, Scipione L. Bortolami M, et al. Among authors: alcaro s. ACS Chem Neurosci. 2021 Nov 3;12(21):4090-4112. doi: 10.1021/acschemneuro.1c00485. Epub 2021 Oct 15. ACS Chem Neurosci. 2021. PMID: 34652128 Free PMC article.
Simple choline esters as potential anti-Alzheimer agents.
Alcaro S, Arcone R, Costa G, De Vita D, Iannone M, Ortuso F, Procopio A, Pasceri R, Rotiroti D, Scipione L. Alcaro S, et al. Curr Pharm Des. 2010;16(6):692-7. doi: 10.2174/138161210790883796. Curr Pharm Des. 2010. PMID: 20388079
(Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies.
D'Ascenzio M, Chimenti P, Gidaro MC, De Monte C, De Vita D, Granese A, Scipione L, Di Santo R, Costa G, Alcaro S, Yáñez M, Carradori S. D'Ascenzio M, et al. Among authors: alcaro s. J Enzyme Inhib Med Chem. 2015 Dec;30(6):908-19. doi: 10.3109/14756366.2014.987138. Epub 2015 Sep 25. J Enzyme Inhib Med Chem. 2015. PMID: 25807300
Drug design, synthesis, in vitro and in silico evaluation of selective monoaminoxidase B inhibitors based on 3-acetyl-2-dichlorophenyl-5-aryl-2,3-dihydro-1,3,4-oxadiazole chemical scaffold.
Distinto S, Meleddu R, Yanez M, Cirilli R, Bianco G, Sanna ML, Arridu A, Cossu P, Cottiglia F, Faggi C, Ortuso F, Alcaro S, Maccioni E. Distinto S, et al. Among authors: alcaro s. Eur J Med Chem. 2016 Jan 27;108:542-552. doi: 10.1016/j.ejmech.2015.12.026. Epub 2015 Dec 17. Eur J Med Chem. 2016. PMID: 26717204
Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress.
Aiello F, Badolato M, Pessina F, Sticozzi C, Maestrini V, Aldinucci C, Luongo L, Guida F, Ligresti A, Artese A, Allarà M, Costa G, Frosini M, Schiano Moriello A, De Petrocellis L, Valacchi G, Alcaro S, Maione S, Di Marzo V, Corelli F, Brizzi A. Aiello F, et al. Among authors: alcaro s. ACS Chem Neurosci. 2016 Jun 15;7(6):737-48. doi: 10.1021/acschemneuro.5b00333. Epub 2016 Mar 22. ACS Chem Neurosci. 2016. PMID: 26942555
265 results