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Page 1
Preclinical characterization of [18F]T-008, a novel PET imaging radioligand for cholesterol 24-hydroxylase.
Koike T, Constantinescu CC, Ikeda S, Nishi T, Sunahara E, Miyamoto M, Cole P, Barret O, Alagille D, Papin C, Morley T, Fowles K, Seibyl J, Tamagnan G, Kuroita T. Koike T, et al. Among authors: kuroita t. Eur J Nucl Med Mol Imaging. 2022 Mar;49(4):1148-1156. doi: 10.1007/s00259-021-05565-z. Epub 2021 Oct 15. Eur J Nucl Med Mol Imaging. 2022. PMID: 34651220 Free PMC article.
Design and synthesis of aryl-piperidine derivatives as potent and selective PET tracers for cholesterol 24-hydroxylase (CH24H).
Ikeda S, Kajita Y, Miyamoto M, Matsumiya K, Ishii T, Nishi T, Gay SC, Lane W, Constantinescu CC, Alagille D, Papin C, Tamagnan G, Kuroita T, Koike T. Ikeda S, et al. Among authors: kuroita t. Eur J Med Chem. 2022 Oct 5;240:114612. doi: 10.1016/j.ejmech.2022.114612. Epub 2022 Jul 14. Eur J Med Chem. 2022. PMID: 35863274 Free article.
Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice.
Nishi T, Kondo S, Miyamoto M, Watanabe S, Hasegawa S, Kondo S, Yano J, Watanabe E, Ishi T, Yoshikawa M, Ando HK, Farnaby W, Fujimoto S, Sunahara E, Ohori M, During MJ, Kuroita T, Koike T. Nishi T, et al. Among authors: kuroita t. Sci Rep. 2020 Oct 13;10(1):17081. doi: 10.1038/s41598-020-74036-6. Sci Rep. 2020. PMID: 33051477 Free PMC article.
Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor.
Imaeda Y, Tokuhara H, Fukase Y, Kanagawa R, Kajimoto Y, Kusumoto K, Kondo M, Snell G, Behnke CA, Kuroita T. Imaeda Y, et al. Among authors: kuroita t. ACS Med Chem Lett. 2016 Sep 12;7(10):933-938. doi: 10.1021/acsmedchemlett.6b00251. eCollection 2016 Oct 13. ACS Med Chem Lett. 2016. PMID: 27774132 Free PMC article.
Development of a series of novel carbon-11 labeled PDE10A inhibitors.
Stepanov V, Miura S, Takano A, Amini N, Nakao R, Hasui T, Nakashima K, Taniguchi T, Kimura H, Kuroita T, Halldin C. Stepanov V, et al. Among authors: kuroita t. J Labelled Comp Radiopharm. 2015 May 15;58(5):202-8. doi: 10.1002/jlcr.3284. Epub 2015 Apr 19. J Labelled Comp Radiopharm. 2015. PMID: 25891816
Novel approach of fragment-based lead discovery applied to renin inhibitors.
Tawada M, Suzuki S, Imaeda Y, Oki H, Snell G, Behnke CA, Kondo M, Tarui N, Tanaka T, Kuroita T, Tomimoto M. Tawada M, et al. Among authors: kuroita t. Bioorg Med Chem. 2016 Nov 15;24(22):6066-6074. doi: 10.1016/j.bmc.2016.09.065. Epub 2016 Sep 28. Bioorg Med Chem. 2016. PMID: 27720325
Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile.
Tokuhara H, Imaeda Y, Fukase Y, Iwanaga K, Taya N, Watanabe K, Kanagawa R, Matsuda K, Kajimoto Y, Kusumoto K, Kondo M, Snell G, Behnke CA, Kuroita T. Tokuhara H, et al. Among authors: kuroita t. Bioorg Med Chem. 2018 Jul 23;26(12):3261-3286. doi: 10.1016/j.bmc.2018.04.051. Epub 2018 Apr 27. Bioorg Med Chem. 2018. PMID: 29754833
47 results