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Evolutionary expansion of polyaspartate motif in the activation peptide of mouse cationic trypsinogen limits autoactivation and protects against pancreatitis.
Orekhova A, Németh BC, Jancsó Z, Geisz A, Mosztbacher D, Demcsák A, Sahin-Tóth M. Orekhova A, et al. Among authors: demcsak a. Am J Physiol Gastrointest Liver Physiol. 2021 Dec 1;321(6):G719-G734. doi: 10.1152/ajpgi.00265.2021. Epub 2021 Oct 13. Am J Physiol Gastrointest Liver Physiol. 2021. PMID: 34643096 Free PMC article.
Measuring digestive protease activation in the mouse pancreas.
Mosztbacher D, Demcsák A, Sahin-Tóth M. Mosztbacher D, et al. Among authors: demcsak a. Pancreatology. 2020 Mar;20(2):288-292. doi: 10.1016/j.pan.2019.12.020. Epub 2019 Dec 26. Pancreatology. 2020. PMID: 31899136 Free PMC article.
Loss-of-function variant in chymotrypsin like elastase 3B (CELA3B) is associated with non-alcoholic chronic pancreatitis.
Tóth A, Demcsák A, Zankl F, Oracz G, Unger LS, Bugert P, Laumen H, Párniczky A, Hegyi P, Rosendahl J, Gambin T, Płoski R, Koziel D, Gluszek S, Lindgren F, Löhr JM, Sahin-Tóth M, Witt H, Rygiel AM, Ewers M, Hegyi E. Tóth A, et al. Among authors: demcsak a. Pancreatology. 2022 Sep;22(6):713-718. doi: 10.1016/j.pan.2022.06.258. Epub 2022 Jun 23. Pancreatology. 2022. PMID: 35773178 Free PMC article.
Arg236 in human chymotrypsin B2 (CTRB2) is a key determinant of high enzyme activity, trypsinogen degradation capacity, and protection against pancreatitis.
Németh BZ, Demcsák A, Micsonai A, Kiss B, Schlosser G, Geisz A, Hegyi E, Sahin-Tóth M, Pál G. Németh BZ, et al. Among authors: demcsak a. Biochim Biophys Acta Proteins Proteom. 2022 Sep 1;1870(9):140831. doi: 10.1016/j.bbapap.2022.140831. Epub 2022 Aug 5. Biochim Biophys Acta Proteins Proteom. 2022. PMID: 35934298 Free PMC article.
26 results