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CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression.
Schneider E, Winzer R, Rissiek A, Ricklefs I, Meyer-Schwesinger C, Ricklefs FL, Bauche A, Behrends J, Reimer R, Brenna S, Wasielewski H, Lauten M, Rissiek B, Puig B, Cortesi F, Magnus T, Fliegert R, Müller CE, Gagliani N, Tolosa E. Schneider E, et al. Nat Commun. 2021 Oct 8;12(1):5911. doi: 10.1038/s41467-021-26134-w. Nat Commun. 2021. PMID: 34625545 Free PMC article.
IL-17A production by renal γδ T cells promotes kidney injury in crescentic GN.
Turner JE, Krebs C, Tittel AP, Paust HJ, Meyer-Schwesinger C, Bennstein SB, Steinmetz OM, Prinz I, Magnus T, Korn T, Stahl RA, Kurts C, Panzer U. Turner JE, et al. J Am Soc Nephrol. 2012 Sep;23(9):1486-95. doi: 10.1681/ASN.2012010040. Epub 2012 Jul 12. J Am Soc Nephrol. 2012. PMID: 22797181 Free PMC article.
Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation.
Danquah W, Meyer-Schwesinger C, Rissiek B, Pinto C, Serracant-Prat A, Amadi M, Iacenda D, Knop JH, Hammel A, Bergmann P, Schwarz N, Assunção J, Rotthier W, Haag F, Tolosa E, Bannas P, Boué-Grabot E, Magnus T, Laeremans T, Stortelers C, Koch-Nolte F. Danquah W, et al. Sci Transl Med. 2016 Nov 23;8(366):366ra162. doi: 10.1126/scitranslmed.aaf8463. Sci Transl Med. 2016. PMID: 27881823
Pathogen-induced tissue-resident memory TH17 (TRM17) cells amplify autoimmune kidney disease.
Krebs CF, Reimers D, Zhao Y, Paust HJ, Bartsch P, Nuñez S, Rosemblatt MV, Hellmig M, Kilian C, Borchers A, Enk LUB, Zinke M, Becker M, Schmid J, Klinge S, Wong MN, Puelles VG, Schmidt C, Bertram T, Stumpf N, Hoxha E, Meyer-Schwesinger C, Lindenmeyer MT, Cohen CD, Rink M, Kurts C, Franzenburg S, Koch-Nolte F, Turner JE, Riedel JH, Huber S, Gagliani N, Huber TB, Wiech T, Rohde H, Bono MR, Bonn S, Panzer U, Mittrücker HW. Krebs CF, et al. Sci Immunol. 2020 Aug 7;5(50):eaba4163. doi: 10.1126/sciimmunol.aba4163. Sci Immunol. 2020. PMID: 32769171
ADP-Ribosylation Regulates the Signaling Function of IFN-γ.
Menzel S, Koudelka T, Rissiek B, Haag F, Meyer-Schwesinger C, Tholey A, Koch-Nolte F. Menzel S, et al. Front Immunol. 2021 Mar 8;12:642545. doi: 10.3389/fimmu.2021.642545. eCollection 2021. Front Immunol. 2021. PMID: 33763084 Free PMC article.
The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration.
Sachs W, Blume L, Loreth D, Schebsdat L, Hatje F, Koehler S, Wedekind U, Sachs M, Zieliniski S, Brand J, Conze C, Florea BI, Heppner F, Krüger E, Rinschen MM, Kretz O, Thünauer R, Meyer-Schwesinger C. Sachs W, et al. Among authors: meyer schwesinger c. Nat Commun. 2024 Mar 1;15(1):1897. doi: 10.1038/s41467-024-46273-0. Nat Commun. 2024. PMID: 38429282 Free PMC article.
106 results