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CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression.
Schneider E, Winzer R, Rissiek A, Ricklefs I, Meyer-Schwesinger C, Ricklefs FL, Bauche A, Behrends J, Reimer R, Brenna S, Wasielewski H, Lauten M, Rissiek B, Puig B, Cortesi F, Magnus T, Fliegert R, Müller CE, Gagliani N, Tolosa E. Schneider E, et al. Among authors: fliegert r. Nat Commun. 2021 Oct 8;12(1):5911. doi: 10.1038/s41467-021-26134-w. Nat Commun. 2021. PMID: 34625545 Free PMC article.
2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist.
Fliegert R, Bauche A, Wolf Pérez AM, Watt JM, Rozewitz MD, Winzer R, Janus M, Gu F, Rosche A, Harneit A, Flato M, Moreau C, Kirchberger T, Wolters V, Potter BVL, Guse AH. Fliegert R, et al. Nat Chem Biol. 2017 Sep;13(9):1036-1044. doi: 10.1038/nchembio.2415. Epub 2017 Jun 26. Nat Chem Biol. 2017. PMID: 28671679 Free PMC article.
NAD binding by human CD38 analyzed by Trp189 fluorescence.
Wolters V, Rosche A, Bauche A, Kulow F, Harneit A, Fliegert R, Guse AH. Wolters V, et al. Among authors: fliegert r. Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1189-1196. doi: 10.1016/j.bbamcr.2018.11.011. Epub 2018 Nov 22. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 30472140 Free article.
P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP.
Johnsen B, Kaschubowski KE, Nader S, Schneider E, Nicola JA, Fliegert R, Wolf IMA, Guse AH, Nikolaev VO, Koch-Nolte F, Haag F. Johnsen B, et al. Among authors: fliegert r. Purinergic Signal. 2019 Jun;15(2):155-166. doi: 10.1007/s11302-019-09654-5. Epub 2019 Apr 23. Purinergic Signal. 2019. PMID: 31016551 Free PMC article.
cADPR Does Not Activate TRPM2.
Riekehr WM, Sander S, Pick J, Tidow H, Bauche A, Guse AH, Fliegert R. Riekehr WM, et al. Among authors: fliegert r. Int J Mol Sci. 2022 Mar 15;23(6):3163. doi: 10.3390/ijms23063163. Int J Mol Sci. 2022. PMID: 35328585 Free PMC article.
Novel CaM-binding motif in its NudT9H domain contributes to temperature sensitivity of TRPM2.
Gattkowski E, Johnsen A, Bauche A, Möckl F, Kulow F, Garcia Alai M, Rutherford TJ, Fliegert R, Tidow H. Gattkowski E, et al. Among authors: fliegert r. Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1162-1170. doi: 10.1016/j.bbamcr.2018.12.010. Epub 2018 Dec 22. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 30584900 Free PMC article.
46 results