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Molecular predictors of response to pembrolizumab in thymic carcinoma.
He Y, Ramesh A, Gusev Y, Bhuvaneshwar K, Giaccone G. He Y, et al. Among authors: giaccone g. Cell Rep Med. 2021 Sep 3;2(9):100392. doi: 10.1016/j.xcrm.2021.100392. eCollection 2021 Sep 21. Cell Rep Med. 2021. PMID: 34622229 Free PMC article. Clinical Trial.
A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors.
Petrini I, Meltzer PS, Kim IK, Lucchi M, Park KS, Fontanini G, Gao J, Zucali PA, Calabrese F, Favaretto A, Rea F, Rodriguez-Canales J, Walker RL, Pineda M, Zhu YJ, Lau C, Killian KJ, Bilke S, Voeller D, Dakshanamurthy S, Wang Y, Giaccone G. Petrini I, et al. Among authors: giaccone g. Nat Genet. 2014 Aug;46(8):844-9. doi: 10.1038/ng.3016. Epub 2014 Jun 29. Nat Genet. 2014. PMID: 24974848 Free PMC article.
Sunitinib in patients with chemotherapy-refractory thymoma and thymic carcinoma: an open-label phase 2 trial.
Thomas A, Rajan A, Berman A, Tomita Y, Brzezniak C, Lee MJ, Lee S, Ling A, Spittler AJ, Carter CA, Guha U, Wang Y, Szabo E, Meltzer P, Steinberg SM, Trepel JB, Loehrer PJ, Giaccone G. Thomas A, et al. Among authors: giaccone g. Lancet Oncol. 2015 Feb;16(2):177-86. doi: 10.1016/S1470-2045(14)71181-7. Epub 2015 Jan 13. Lancet Oncol. 2015. PMID: 25592632 Free PMC article. Clinical Trial.
PI3K as a Potential Therapeutic Target in Thymic Epithelial Tumors.
Alberobello AT, Wang Y, Beerkens FJ, Conforti F, McCutcheon JN, Rao G, Raffeld M, Liu J, Rahhal R, Zhang YW, Giaccone G. Alberobello AT, et al. Among authors: giaccone g. J Thorac Oncol. 2016 Aug;11(8):1345-1356. doi: 10.1016/j.jtho.2016.04.013. Epub 2016 Apr 24. J Thorac Oncol. 2016. PMID: 27117832 Free PMC article.
Pembrolizumab in patients with thymic carcinoma: a single-arm, single-centre, phase 2 study.
Giaccone G, Kim C, Thompson J, McGuire C, Kallakury B, Chahine JJ, Manning M, Mogg R, Blumenschein WM, Tan MT, Subramaniam DS, Liu SV, Kaplan IM, McCutcheon JN. Giaccone G, et al. Lancet Oncol. 2018 Mar;19(3):347-355. doi: 10.1016/S1470-2045(18)30062-7. Epub 2018 Jan 26. Lancet Oncol. 2018. PMID: 29395863 Free PMC article. Clinical Trial.
The Integrated Genomic Landscape of Thymic Epithelial Tumors.
Radovich M, Pickering CR, Felau I, Ha G, Zhang H, Jo H, Hoadley KA, Anur P, Zhang J, McLellan M, Bowlby R, Matthew T, Danilova L, Hegde AM, Kim J, Leiserson MDM, Sethi G, Lu C, Ryan M, Su X, Cherniack AD, Robertson G, Akbani R, Spellman P, Weinstein JN, Hayes DN, Raphael B, Lichtenberg T, Leraas K, Zenklusen JC; Cancer Genome Atlas Network; Fujimoto J, Scapulatempo-Neto C, Moreira AL, Hwang D, Huang J, Marino M, Korst R, Giaccone G, Gokmen-Polar Y, Badve S, Rajan A, Ströbel P, Girard N, Tsao MS, Marx A, Tsao AS, Loehrer PJ. Radovich M, et al. Among authors: giaccone g. Cancer Cell. 2018 Feb 12;33(2):244-258.e10. doi: 10.1016/j.ccell.2018.01.003. Cancer Cell. 2018. PMID: 29438696 Free PMC article.
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