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Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA.
J Med Chem. 2021 Oct 28;64(20):15214-15249. doi: 10.1021/acs.jmedchem.1c01250. Epub 2021 Oct 6.
J Med Chem. 2021.
PMID: 34614347
Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors.
Corrigan TS, Lotti Diaz LM, Border SE, Ratigan SC, Kasper KQ, Sojka D, Fajtova P, Caffrey CR, Salvesen GS, McElroy CA, Hadad CM, Doğan Ekici Ö.
Corrigan TS, et al. Among authors: ratigan sc.
J Enzyme Inhib Med Chem. 2020 Dec;35(1):1387-1402. doi: 10.1080/14756366.2020.1781107.
J Enzyme Inhib Med Chem. 2020.
PMID: 32633155
Free PMC article.
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Enhancing ferryl accumulation in H2O2-dependent cytochrome P450s.
Amaya JA, Manley OM, Bian JC, Rutland CD, Leschinsky N, Ratigan SC, Makris TM.
Amaya JA, et al. Among authors: ratigan sc.
J Inorg Biochem. 2024 Mar;252:112458. doi: 10.1016/j.jinorgbio.2023.112458. Epub 2023 Dec 20.
J Inorg Biochem. 2024.
PMID: 38141432
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Divergent mechanisms of iron-containing enzymes for hydrocarbon biosynthesis.
Wise CE, Grant JL, Amaya JA, Ratigan SC, Hsieh CH, Manley OM, Makris TM.
Wise CE, et al. Among authors: ratigan sc.
J Biol Inorg Chem. 2017 Apr;22(2-3):221-235. doi: 10.1007/s00775-016-1425-0. Epub 2016 Dec 21.
J Biol Inorg Chem. 2017.
PMID: 28004185
Review.
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