Cummings JE - Search Results

1

Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA.

Lu Y, Vibhute S, Li L, Okumu A, Ratigan SC, Nolan S, Papa JL, Mann CA, English A, Chen A, Seffernick JT, Koci B, Duncan LR, Roth B, Cummings JE, Slayden RA, Lindert S, McElroy CA, Wozniak DJ, Yalowich J, Mitton-Fry MJ. Lu Y, et al. Among authors: cummings je. J Med Chem. 2021 Oct 28;64(20):15214-15249. doi: 10.1021/acs.jmedchem.1c01250. Epub 2021 Oct 6. J Med Chem. 2021. PMID: 34614347

2

Mechanism and inhibition of the FabI enoyl-ACP reductase from Burkholderia pseudomallei.

Liu N, Cummings JE, England K, Slayden RA, Tonge PJ. Liu N, et al. Among authors: cummings je. J Antimicrob Chemother. 2011 Mar;66(3):564-73. doi: 10.1093/jac/dkq509. Epub 2011 Jan 22. J Antimicrob Chemother. 2011. PMID: 21393229 Free PMC article.

3

The Francisella tularensis FabI enoyl-acyl carrier protein reductase gene is essential to bacterial viability and is expressed during infection.

Kingry LC, Cummings JE, Brookman KW, Bommineni GR, Tonge PJ, Slayden RA. Kingry LC, et al. Among authors: cummings je. J Bacteriol. 2013 Jan;195(2):351-8. doi: 10.1128/JB.01957-12. Epub 2012 Nov 9. J Bacteriol. 2013. PMID: 23144254 Free PMC article.

4

Benzimidazole-based antibacterial agents against Francisella tularensis.

Kumar K, Awasthi D, Lee SY, Cummings JE, Knudson SE, Slayden RA, Ojima I. Kumar K, et al. Among authors: cummings je. Bioorg Med Chem. 2013 Jun 1;21(11):3318-26. doi: 10.1016/j.bmc.2013.02.059. Epub 2013 Apr 3. Bioorg Med Chem. 2013. PMID: 23623254 Free PMC article.

5

The Burkholderia pseudomallei enoyl-acyl carrier protein reductase FabI1 is essential for in vivo growth and is the target of a novel chemotherapeutic with efficacy.

Cummings JE, Kingry LC, Rholl DA, Schweizer HP, Tonge PJ, Slayden RA. Cummings JE, et al. Antimicrob Agents Chemother. 2014;58(2):931-5. doi: 10.1128/AAC.00176-13. Epub 2013 Nov 25. Antimicrob Agents Chemother. 2014. PMID: 24277048 Free PMC article.

6

Substituted diphenyl ethers as a novel chemotherapeutic platform against Burkholderia pseudomallei.

Cummings JE, Beaupre AJ, Knudson SE, Liu N, Yu W, Neckles C, Wang H, Khanna A, Bommineni GR, Trunck LA, Schweizer HP, Tonge PJ, Slayden RA. Cummings JE, et al. Antimicrob Agents Chemother. 2014;58(3):1646-51. doi: 10.1128/AAC.02296-13. Epub 2013 Dec 30. Antimicrob Agents Chemother. 2014. PMID: 24379198 Free PMC article.

7

Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitor.

Schiebel J, Chang A, Shah S, Lu Y, Liu L, Pan P, Hirschbeck MW, Tareilus M, Eltschkner S, Yu W, Cummings JE, Knudson SE, Bommineni GR, Walker SG, Slayden RA, Sotriffer CA, Tonge PJ, Kisker C. Schiebel J, et al. Among authors: cummings je. J Biol Chem. 2014 Jun 6;289(23):15987-6005. doi: 10.1074/jbc.M113.532804. Epub 2014 Apr 16. J Biol Chem. 2014. PMID: 24739388 Free PMC article.

8

Thiolactomycin-Based Inhibitors of Bacterial β-Ketoacyl-ACP Synthases with in Vivo Activity.

Bommineni GR, Kapilashrami K, Cummings JE, Lu Y, Knudson SE, Gu C, Walker SG, Slayden RA, Tonge PJ. Bommineni GR, et al. Among authors: cummings je. J Med Chem. 2016 Jun 9;59(11):5377-90. doi: 10.1021/acs.jmedchem.6b00236. Epub 2016 May 24. J Med Chem. 2016. PMID: 27187871 Free PMC article.

9

Immune Modulation as an Effective Adjunct Post-exposure Therapeutic for B. pseudomallei.

Wilson WJ, Afzali MF, Cummings JE, Legare ME, Tjalkens RB, Allen CP, Slayden RA, Hanneman WH. Wilson WJ, et al. Among authors: cummings je. PLoS Negl Trop Dis. 2016 Oct 28;10(10):e0005065. doi: 10.1371/journal.pntd.0005065. eCollection 2016 Oct. PLoS Negl Trop Dis. 2016. PMID: 27792775 Free PMC article.

10

Formulation studies of InhA inhibitors and combination therapy to improve efficacy against Mycobacterium tuberculosis.

Knudson SE, Cummings JE, Bommineni GR, Pan P, Tonge PJ, Slayden RA. Knudson SE, et al. Among authors: cummings je. Tuberculosis (Edinb). 2016 Dec;101:8-14. doi: 10.1016/j.tube.2016.07.016. Epub 2016 Aug 3. Tuberculosis (Edinb). 2016. PMID: 27865404 Free PMC article.

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