Laitinen T - Search Results

1

Identification of Key Amino Acids that Impact Organic Solute Transporter α/β (OSTα/β).

Murphy WA, Beaudoin JJ, Laitinen T, Sjöstedt N, Malinen MM, Ho H, Swaan PW, Honkakoski P, Brouwer KLR. Murphy WA, et al. Among authors: laitinen t. Mol Pharmacol. 2021 Dec;100(6):599-608. doi: 10.1124/molpharm.121.000345. Epub 2021 Oct 1. Mol Pharmacol. 2021. PMID: 34599072 Free PMC article.

2

Use of comprehensive screening methods to detect selective human CAR activators.

Küblbeck J, Laitinen T, Jyrkkärinne J, Rousu T, Tolonen A, Abel T, Kortelainen T, Uusitalo J, Korjamo T, Honkakoski P, Molnár F. Küblbeck J, et al. Among authors: laitinen t. Biochem Pharmacol. 2011 Dec 15;82(12):1994-2007. doi: 10.1016/j.bcp.2011.08.027. Epub 2011 Sep 8. Biochem Pharmacol. 2011. PMID: 21924250

3

New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists.

Küblbeck J, Jyrkkärinne J, Molnár F, Kuningas T, Patel J, Windshügel B, Nevalainen T, Laitinen T, Sippl W, Poso A, Honkakoski P. Küblbeck J, et al. Among authors: laitinen t. Mol Pharm. 2011 Dec 5;8(6):2424-33. doi: 10.1021/mp2003658. Epub 2011 Nov 1. Mol Pharm. 2011. PMID: 22044162

4

Molecular dynamics simulations for human CAR inverse agonists.

Jyrkkärinne J, Küblbeck J, Pulkkinen J, Honkakoski P, Laatikainen R, Poso A, Laitinen T. Jyrkkärinne J, et al. Among authors: laitinen t. J Chem Inf Model. 2012 Feb 27;52(2):457-64. doi: 10.1021/ci200432k. Epub 2012 Jan 25. J Chem Inf Model. 2012. PMID: 22233089

5

Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency.

Laitinen T, Navia-Paldanius D, Rytilahti R, Marjamaa JJ, Kařízková J, Parkkari T, Pantsar T, Poso A, Laitinen JT, Savinainen JR. Laitinen T, et al. Among authors: laitinen jt. Mol Pharmacol. 2014 Mar;85(3):510-9. doi: 10.1124/mol.113.090795. Epub 2013 Dec 24. Mol Pharmacol. 2014. PMID: 24368842

6

Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL).

Savinainen JR, Kansanen E, Pantsar T, Navia-Paldanius D, Parkkari T, Lehtonen M, Laitinen T, Nevalainen T, Poso A, Levonen AL, Laitinen JT. Savinainen JR, et al. Among authors: laitinen t, laitinen jt. Mol Pharmacol. 2014 Nov;86(5):522-35. doi: 10.1124/mol.114.094284. Epub 2014 Aug 19. Mol Pharmacol. 2014. PMID: 25140003

7

Molecular characteristics supporting l-Type amino acid transporter 1 (LAT1)-mediated translocation.

Kärkkäinen J, Laitinen T, Markowicz-Piasecka M, Montaser A, Lehtonen M, Rautio J, Gynther M, Poso A, Huttunen KM. Kärkkäinen J, et al. Among authors: laitinen t. Bioorg Chem. 2021 Jul;112:104921. doi: 10.1016/j.bioorg.2021.104921. Epub 2021 Apr 22. Bioorg Chem. 2021. PMID: 33933805

8

Structural Features Affecting the Interactions and Transportability of LAT1-Targeted Phenylalanine Drug Conjugates.

Bahrami K, Järvinen J, Laitinen T, Reinisalo M, Honkakoski P, Poso A, Huttunen KM, Rautio J. Bahrami K, et al. Among authors: laitinen t. Mol Pharm. 2023 Jan 2;20(1):206-218. doi: 10.1021/acs.molpharmaceut.2c00594. Epub 2022 Nov 17. Mol Pharm. 2023. PMID: 36394563 Free PMC article.

9

Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors.

Patel JZ, Nevalainen TJ, Savinainen JR, Adams Y, Laitinen T, Runyon RS, Vaara M, Ahenkorah S, Kaczor AA, Navia-Paldanius D, Gynther M, Aaltonen N, Joharapurkar AA, Jain MR, Haka AS, Maxfield FR, Laitinen JT, Parkkari T. Patel JZ, et al. Among authors: laitinen t, laitinen jt. ChemMedChem. 2015 Feb;10(2):253-65. doi: 10.1002/cmdc.201402453. Epub 2014 Dec 11. ChemMedChem. 2015. PMID: 25504894 Free PMC article.

10

Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors.

Patel JZ, van Bruchem J, Laitinen T, Kaczor AA, Navia-Paldanius D, Parkkari T, Savinainen JR, Laitinen JT, Nevalainen TJ. Patel JZ, et al. Among authors: laitinen t, laitinen jt. Bioorg Med Chem. 2015 Oct 1;23(19):6335-45. doi: 10.1016/j.bmc.2015.08.030. Epub 2015 Aug 28. Bioorg Med Chem. 2015. PMID: 26344596

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