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Computer-Aided Design and Synthesis of a New Class of PEX14 Inhibitors: Substituted 2,3,4,5-Tetrahydrobenzo[F][1,4]oxazepines as Potential New Trypanocidal Agents.
Fino R, Lenhart D, Kalel VC, Softley CA, Napolitano V, Byrne R, Schliebs W, Dawidowski M, Erdmann R, Sattler M, Schneider G, Plettenburg O, Popowicz GM. Fino R, et al. Among authors: sattler m. J Chem Inf Model. 2021 Oct 25;61(10):5256-5268. doi: 10.1021/acs.jcim.1c00472. Epub 2021 Oct 1. J Chem Inf Model. 2021. PMID: 34597510 Free article.
Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism.
Haslbeck V, Drazic A, Eckl JM, Alte F, Helmuth M, Popowicz G, Schmidt W, Braun F, Weiwad M, Fischer G, Gemmecker G, Sattler M, Striggow F, Groll M, Richter K. Haslbeck V, et al. Among authors: sattler m. Biosci Rep. 2015 Apr 20;35(3):e00210. doi: 10.1042/BSR20150042. Biosci Rep. 2015. PMID: 26182372 Free PMC article.
Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.
Dawidowski M, Emmanouilidis L, Kalel VC, Tripsianes K, Schorpp K, Hadian K, Kaiser M, Mäser P, Kolonko M, Tanghe S, Rodriguez A, Schliebs W, Erdmann R, Sattler M, Popowicz GM. Dawidowski M, et al. Among authors: sattler m. Science. 2017 Mar 31;355(6332):1416-1420. doi: 10.1126/science.aal1807. Science. 2017. PMID: 28360328
Identification of small-molecule inhibitors of USP2a.
Tomala MD, Magiera-Mularz K, Kubica K, Krzanik S, Zieba B, Musielak B, Pustula M, Popowicz GM, Sattler M, Dubin G, Skalniak L, Holak TA. Tomala MD, et al. Among authors: sattler m. Eur J Med Chem. 2018 Apr 25;150:261-267. doi: 10.1016/j.ejmech.2018.03.009. Epub 2018 Mar 5. Eur J Med Chem. 2018. PMID: 29529503
610 results