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Suppression of Colon Tumorigenesis in Mutant Apc Mice by a Novel PDE10 Inhibitor that Reduces Oncogenic β-Catenin.
Lee KJ, Chang WL, Chen X, Valiyaveettil J, Ramirez-Alcantara V, Gavin E, Musiyenko A, Madeira da Silva L, Annamdevula NS, Leavesley SJ, Ward A, Mattox T, Lindsey AS, Andrews J, Zhu B, Wood C, Neese A, Nguyen A, Berry K, Maxuitenko Y, Moyer MP, Nurmemmedov E, Gorman G, Coward L, Zhou G, Keeton AB, Cooper HS, Clapper ML, Piazza GA. Lee KJ, et al. Among authors: valiyaveettil j. Cancer Prev Res (Phila). 2021 Nov;14(11):995-1008. doi: 10.1158/1940-6207.CAPR-21-0208. Epub 2021 Sep 28. Cancer Prev Res (Phila). 2021. PMID: 34584001 Free PMC article.
Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling.
Zhu B, Lindsey A, Li N, Lee K, Ramirez-Alcantara V, Canzoneri JC, Fajardo A, Madeira da Silva L, Thomas M, Piazza JT, Yet L, Eberhardt BT, Gurpinar E, Otali D, Grizzle W, Valiyaveettil J, Chen X, Keeton AB, Piazza GA. Zhu B, et al. Among authors: valiyaveettil j. Oncotarget. 2017 Aug 27;8(41):69264-69280. doi: 10.18632/oncotarget.20566. eCollection 2017 Sep 19. Oncotarget. 2017. PMID: 29050202 Free PMC article.
Unique functional and structural properties of the LRRK2 protein ATP-binding pocket.
Liu Z, Galemmo RA Jr, Fraser KB, Moehle MS, Sen S, Volpicelli-Daley LA, DeLucas LJ, Ross LJ, Valiyaveettil J, Moukha-Chafiq O, Pathak AK, Ananthan S, Kezar H, White EL, Gupta V, Maddry JA, Suto MJ, West AB. Liu Z, et al. Among authors: valiyaveettil j. J Biol Chem. 2014 Nov 21;289(47):32937-51. doi: 10.1074/jbc.M114.602318. Epub 2014 Sep 16. J Biol Chem. 2014. PMID: 25228699 Free PMC article.
Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors.
Girijavallabhan VM, Alvarez C, Bennett F, Chen L, Gavalas S, Huang Y, Kim SH, Kosinski A, Pinto P, Rizvi R, Rossman R, Shankar B, Tong L, Velazquez F, Venkatraman S, Verma VA, Kozlowski J, Shih NY, Piwinski JJ, MacCoss M, Kwong CD, Bansal N, Clark JL, Fowler AT, Kezar HS 3rd, Valiyaveettil J, Reynolds RC, Maddry JA, Ananthan S, Secrist JA 3rd, Li C, Chase R, Curry S, Huang HC, Tong X, Njoroge FG, Arasappan A. Girijavallabhan VM, et al. Among authors: valiyaveettil j. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5652-7. doi: 10.1016/j.bmcl.2012.06.099. Epub 2012 Jul 15. Bioorg Med Chem Lett. 2012. PMID: 22858143
New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine.
McCloskey DE, Bale S, Secrist JA 3rd, Tiwari A, Moss TH 3rd, Valiyaveettil J, Brooks WH, Guida WC, Pegg AE, Ealick SE. McCloskey DE, et al. Among authors: valiyaveettil j. J Med Chem. 2009 Mar 12;52(5):1388-407. doi: 10.1021/jm801126a. J Med Chem. 2009. PMID: 19209891 Free PMC article.
A Novel Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth in Mouse Models of GI Cancer.
Foote JB, Mattox TE, Keeton AB, Chen X, Smith FT, Berry KL, Holmes T, Wang J, Huang CH, Ward AB, Hardy C, Fleten KG, Flatmark K, Yoon KJ, Sarvesh S, Ganji PN, Maxuitenko Y, Valiyaveettil J, Carstens JL, Buchsbaum DJ, Yang J, Zhou G, Nurmemmedov E, Babic I, Gaponenko V, Abdelkarim H, Mitra AK, Boyd MR, Manne U, Bae S, El-Rayes BF, Piazza GA. Foote JB, et al. Among authors: valiyaveettil j. bioRxiv [Preprint]. 2024 Jan 24:2023.05.17.541233. doi: 10.1101/2023.05.17.541233. bioRxiv. 2024. PMID: 38328254 Free PMC article. Preprint.
Selective caveolin-1-dependent endocytosis of glycosphingolipids.
Singh RD, Puri V, Valiyaveettil JT, Marks DL, Bittman R, Pagano RE. Singh RD, et al. Among authors: valiyaveettil jt. Mol Biol Cell. 2003 Aug;14(8):3254-65. doi: 10.1091/mbc.e02-12-0809. Epub 2003 May 18. Mol Biol Cell. 2003. PMID: 12925761 Free PMC article.
11 results