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4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads.
Schäker-Hübner L, Warstat R, Ahlert H, Mishra P, Kraft FB, Schliehe-Diecks J, Schöler A, Borkhardt A, Breit B, Bhatia S, Hügle M, Günther S, Hansen FK. Schäker-Hübner L, et al. Among authors: breit b. J Med Chem. 2021 Oct 14;64(19):14620-14646. doi: 10.1021/acs.jmedchem.1c01119. Epub 2021 Sep 28. J Med Chem. 2021. PMID: 34582215
Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1).
Ostrovskyi D, Rumpf T, Eib J, Lumbroso A, Slynko I, Klaeger S, Heinzlmeir S, Forster M, Gehringer M, Pfaffenrot E, Bauer SM, Schmidtkunz K, Wenzler S, Metzger E, Kuster B, Laufer S, Schüle R, Sippl W, Breit B, Jung M. Ostrovskyi D, et al. Among authors: breit b. Future Med Chem. 2016 Sep;8(13):1537-51. doi: 10.4155/fmc-2016-0132. Epub 2016 Aug 30. Future Med Chem. 2016. PMID: 27572962
Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.
Hügle M, Lucas X, Ostrovskyi D, Regenass P, Gerhardt S, Einsle O, Hau M, Jung M, Breit B, Günther S, Wohlwend D. Hügle M, et al. Among authors: breit b. Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12476-12480. doi: 10.1002/anie.201705516. Epub 2017 Sep 7. Angew Chem Int Ed Engl. 2017. PMID: 28766825
A novel pan-selective bromodomain inhibitor for epigenetic drug design.
Warstat R, Pervaiz M, Regenass P, Amann M, Schmidtkunz K, Einsle O, Jung M, Breit B, Hügle M, Günther S. Warstat R, et al. Among authors: breit b. Eur J Med Chem. 2023 Mar 5;249:115139. doi: 10.1016/j.ejmech.2023.115139. Epub 2023 Jan 25. Eur J Med Chem. 2023. PMID: 36736153
193 results