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Cathepsin S Evokes PAR2-Dependent Pain in Oral Squamous Cell Carcinoma Patients and Preclinical Mouse Models.
Tu NH, Inoue K, Chen E, Anderson BM, Sawicki CM, Scheff NN, Tran HD, Kim DH, Alemu RG, Yang L, Dolan JC, Liu CZ, Janal MN, Latorre R, Jensen DD, Bunnett NW, Edgington-Mitchell LE, Schmidt BL. Tu NH, et al. Among authors: bunnett nw. Cancers (Basel). 2021 Sep 19;13(18):4697. doi: 10.3390/cancers13184697. Cancers (Basel). 2021. PMID: 34572924 Free PMC article.
The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.
Jensen DD, Godfrey CB, Niklas C, Canals M, Kocan M, Poole DP, Murphy JE, Alemi F, Cottrell GS, Korbmacher C, Lambert NA, Bunnett NW, Corvera CU. Jensen DD, et al. Among authors: bunnett nw. J Biol Chem. 2013 Aug 9;288(32):22942-60. doi: 10.1074/jbc.M113.455774. Epub 2013 Jul 1. J Biol Chem. 2013. PMID: 23818521 Free PMC article.
Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.
Zhao P, Lieu T, Barlow N, Metcalf M, Veldhuis NA, Jensen DD, Kocan M, Sostegni S, Haerteis S, Baraznenok V, Henderson I, Lindström E, Guerrero-Alba R, Valdez-Morales EE, Liedtke W, McIntyre P, Vanner SJ, Korbmacher C, Bunnett NW. Zhao P, et al. Among authors: bunnett nw. J Biol Chem. 2014 Sep 26;289(39):27215-27234. doi: 10.1074/jbc.M114.599712. Epub 2014 Aug 12. J Biol Chem. 2014. PMID: 25118282 Free PMC article.
Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe.
Barlow N, Nasser Y, Zhao P, Sharma N, Guerrero-Alba R, Edgington-Mitchell LE, Lieu T, Veldhuis NA, Poole DP, Conner JW, Lindström E, Craig AW, Graham B, Vanner SJ, Bunnett NW. Barlow N, et al. Among authors: bunnett nw. Neurogastroenterol Motil. 2015 Nov;27(11):1675-80. doi: 10.1111/nmo.12656. Epub 2015 Aug 24. Neurogastroenterol Motil. 2015. PMID: 26303377
Legumain is activated in macrophages during pancreatitis.
Edgington-Mitchell LE, Wartmann T, Fleming AK, Gocheva V, van der Linden WA, Withana NP, Verdoes M, Aurelio L, Edgington-Mitchell D, Lieu T, Parker BS, Graham B, Reinheckel T, Furness JB, Joyce JA, Storz P, Halangk W, Bogyo M, Bunnett NW. Edgington-Mitchell LE, et al. Among authors: bunnett nw. Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G548-60. doi: 10.1152/ajpgi.00047.2016. Epub 2016 Aug 11. Am J Physiol Gastrointest Liver Physiol. 2016. PMID: 27514475 Free PMC article.
333 results