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Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics.
Boeynaems S, Bogaert E, Kovacs D, Konijnenberg A, Timmerman E, Volkov A, Guharoy M, De Decker M, Jaspers T, Ryan VH, Janke AM, Baatsen P, Vercruysse T, Kolaitis RM, Daelemans D, Taylor JP, Kedersha N, Anderson P, Impens F, Sobott F, Schymkowitz J, Rousseau F, Fawzi NL, Robberecht W, Van Damme P, Tompa P, Van Den Bosch L. Boeynaems S, et al. Among authors: baatsen p. Mol Cell. 2017 Mar 16;65(6):1044-1055.e5. doi: 10.1016/j.molcel.2017.02.013. Mol Cell. 2017. PMID: 28306503 Free PMC article.
HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients.
Guo W, Naujock M, Fumagalli L, Vandoorne T, Baatsen P, Boon R, Ordovás L, Patel A, Welters M, Vanwelden T, Geens N, Tricot T, Benoy V, Steyaert J, Lefebvre-Omar C, Boesmans W, Jarpe M, Sterneckert J, Wegner F, Petri S, Bohl D, Vanden Berghe P, Robberecht W, Van Damme P, Verfaillie C, Van Den Bosch L. Guo W, et al. Among authors: baatsen p. Nat Commun. 2017 Oct 11;8(1):861. doi: 10.1038/s41467-017-00911-y. Nat Commun. 2017. PMID: 29021520 Free PMC article.
Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition.
Stoklund Dittlau K, Krasnow EN, Fumagalli L, Vandoorne T, Baatsen P, Kerstens A, Giacomazzi G, Pavie B, Rossaert E, Beckers J, Sampaolesi M, Van Damme P, Van Den Bosch L. Stoklund Dittlau K, et al. Among authors: baatsen p. Stem Cell Reports. 2021 Sep 14;16(9):2213-2227. doi: 10.1016/j.stemcr.2021.03.029. Epub 2021 Apr 22. Stem Cell Reports. 2021. PMID: 33891869 Free PMC article.
FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms.
Stoklund Dittlau K, Terrie L, Baatsen P, Kerstens A, De Swert L, Janky R, Corthout N, Masrori P, Van Damme P, Hyttel P, Meyer M, Thorrez L, Freude K, Van Den Bosch L. Stoklund Dittlau K, et al. Among authors: baatsen p. Mol Neurodegener. 2023 Jan 18;18(1):5. doi: 10.1186/s13024-022-00591-3. Mol Neurodegener. 2023. PMID: 36653804 Free PMC article.
Sequence-dependent internalization of aggregating peptides.
Couceiro JR, Gallardo R, De Smet F, De Baets G, Baatsen P, Annaert W, Roose K, Saelens X, Schymkowitz J, Rousseau F. Couceiro JR, et al. Among authors: baatsen p. J Biol Chem. 2015 Jan 2;290(1):242-58. doi: 10.1074/jbc.M114.586636. Epub 2014 Nov 12. J Biol Chem. 2015. PMID: 25391649 Free PMC article.
75 results