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Semysinthetic biflavonoid Morelloflavone-7,4',7″,3‴,4‴-penta-O-butanoyl is a more potent inhibitor of Proprotein Convertases Subtilisin/Kexin PC1/3 than Kex2 and Furin.
de Souza AA, de Andrade DM, Siqueira FDS, Di Iorio JF, Veloso MP, Coelho CM, Viegas Junior C, Gontijo VS, Dos Santos MH, Meneghetti MCZ, Nader HB, Tersariol ILDS, Juliano L, Juliano MA, Judice WAS. de Souza AA, et al. Among authors: viegas junior c. Biochim Biophys Acta Gen Subj. 2021 Dec;1865(12):130016. doi: 10.1016/j.bbagen.2021.130016. Epub 2021 Sep 22. Biochim Biophys Acta Gen Subj. 2021. PMID: 34560176
Leishmanicidal, antiproteolytic and antioxidant evaluation of natural biflavonoids isolated from Garcinia brasiliensis and their semisynthetic derivatives.
Gontijo VS, Judice WA, Codonho B, Pereira IO, Assis DM, Januário JP, Caroselli EE, Juliano MA, de Carvalho Dosatti A, Marques MJ, Viegas Junior C, Henrique dos Santos M. Gontijo VS, et al. Among authors: viegas junior c. Eur J Med Chem. 2012 Dec;58:613-23. doi: 10.1016/j.ejmech.2012.06.021. Epub 2012 Jun 28. Eur J Med Chem. 2012. PMID: 23178961
Alkaloids derived from flowers of Senna spectabilis, (-)-cassine and (-)-spectaline, have antiproliferative activity on HepG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression.
Pereira RM, Ferreira-Silva GÁ, Pivatto M, Santos Lde Á, Bolzani Vda S, Chagas de Paula DA, Oliveira JC, Viegas Júnior C, Ionta M. Pereira RM, et al. Among authors: viegas junior c. Toxicol In Vitro. 2016 Mar;31:86-92. doi: 10.1016/j.tiv.2015.11.018. Epub 2015 Nov 23. Toxicol In Vitro. 2016. PMID: 26616281