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Semysinthetic biflavonoid Morelloflavone-7,4',7″,3‴,4‴-penta-O-butanoyl is a more potent inhibitor of Proprotein Convertases Subtilisin/Kexin PC1/3 than Kex2 and Furin.
Biochim Biophys Acta Gen Subj. 2021 Dec;1865(12):130016. doi: 10.1016/j.bbagen.2021.130016. Epub 2021 Sep 22.
Biochim Biophys Acta Gen Subj. 2021.
PMID: 34560176
Leishmanicidal, antiproteolytic and antioxidant evaluation of natural biflavonoids isolated from Garcinia brasiliensis and their semisynthetic derivatives.
Gontijo VS, Judice WA, Codonho B, Pereira IO, Assis DM, Januário JP, Caroselli EE, Juliano MA, de Carvalho Dosatti A, Marques MJ, Viegas Junior C, Henrique dos Santos M.
Gontijo VS, et al. Among authors: viegas junior c.
Eur J Med Chem. 2012 Dec;58:613-23. doi: 10.1016/j.ejmech.2012.06.021. Epub 2012 Jun 28.
Eur J Med Chem. 2012.
PMID: 23178961
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Promising synergistic activity of fluconazole with bioactive Guttiferone-A and derivatives against non-albicans Candida species.
Ribeiro de Carvalho R, Chaves Silva N, Cusinato M, Tranches Dias KS, Dos Santos MH, Viegas Junior C, Gonçalves Silva É, Tranches Dias AL.
Ribeiro de Carvalho R, et al. Among authors: viegas junior c.
J Mycol Med. 2018 Dec;28(4):645-650. doi: 10.1016/j.mycmed.2018.07.006. Epub 2018 Aug 10.
J Mycol Med. 2018.
PMID: 30104135
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Molecular hybridization: a useful tool in the design of new drug prototypes.
Viegas-Junior C, Danuello A, da Silva Bolzani V, Barreiro EJ, Fraga CA.
Viegas-Junior C, et al.
Curr Med Chem. 2007;14(17):1829-52. doi: 10.2174/092986707781058805.
Curr Med Chem. 2007.
PMID: 17627520
Review.
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Alkaloids derived from flowers of Senna spectabilis, (-)-cassine and (-)-spectaline, have antiproliferative activity on HepG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression.
Pereira RM, Ferreira-Silva GÁ, Pivatto M, Santos Lde Á, Bolzani Vda S, Chagas de Paula DA, Oliveira JC, Viegas Júnior C, Ionta M.
Pereira RM, et al. Among authors: viegas junior c.
Toxicol In Vitro. 2016 Mar;31:86-92. doi: 10.1016/j.tiv.2015.11.018. Epub 2015 Nov 23.
Toxicol In Vitro. 2016.
PMID: 26616281
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Mass spectrometry for characterization of homologous piperidine alkaloids and their activity as acetylcholinesterase inhibitors.
Freitas TR, Danuello A, Viegas Júnior C, Bolzani VS, Pivatto M.
Freitas TR, et al. Among authors: viegas junior c.
Rapid Commun Mass Spectrom. 2018 Aug 15;32(15):1303-1310. doi: 10.1002/rcm.8172.
Rapid Commun Mass Spectrom. 2018.
PMID: 29785738
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