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Biocatalysis in Drug Design: Engineered Reductive Aminases (RedAms) Are Used to Access Chiral Building Blocks with Multiple Stereocenters.
Casamajo AR, Yu Y, Schnepel C, Morrill C, Barker R, Levy CW, Finnigan J, Spelling V, Westerlund K, Petchey M, Sheppard RJ, Lewis RJ, Falcioni F, Hayes MA, Turner NJ. Casamajo AR, et al. Among authors: lewis rj. J Am Chem Soc. 2023 Oct 11;145(40):22041-22046. doi: 10.1021/jacs.3c07010. Epub 2023 Oct 2. J Am Chem Soc. 2023. PMID: 37782882 Free PMC article.
Impact of Excited-State Antiaromaticity Relief in a Fundamental Benzene Photoreaction Leading to Substituted Bicyclo[3.1.0]hexenes.
Slanina T, Ayub R, Toldo J, Sundell J, Rabten W, Nicaso M, Alabugin I, Fdez Galván I, Gupta AK, Lindh R, Orthaber A, Lewis RJ, Grönberg G, Bergman J, Ottosson H. Slanina T, et al. Among authors: lewis rj. J Am Chem Soc. 2020 Jun 24;142(25):10942-10954. doi: 10.1021/jacs.9b13769. Epub 2020 Jun 11. J Am Chem Soc. 2020. PMID: 32456426 Free PMC article.
Saccharin Aza Bioisosteres-Synthesis and Preclinical Property Comparisons.
Chen Y, Aurell CJ, Pettersen A, Lewis RJ, Hayes MA, Lepistö M, Jonson AC, Leek H, Thunberg L. Chen Y, et al. Among authors: lewis rj. ACS Med Chem Lett. 2017 May 1;8(6):672-677. doi: 10.1021/acsmedchemlett.7b00137. eCollection 2017 Jun 8. ACS Med Chem Lett. 2017. PMID: 28626531 Free PMC article.
HSQC Spectra Simulation and Matching for Molecular Identification.
Priessner M, Lewis RJ, Johansson MJ, Goodman JM, Janet JP, Tomberg A. Priessner M, et al. Among authors: lewis rj. J Chem Inf Model. 2024 Apr 22;64(8):3180-3191. doi: 10.1021/acs.jcim.3c01735. Epub 2024 Mar 27. J Chem Inf Model. 2024. PMID: 38533705
Fragment-Based Discovery of Novel Allosteric MEK1 Binders.
Di Fruscia P, Edfeldt F, Shamovsky I, Collie GW, Aagaard A, Barlind L, Börjesson U, Hansson EL, Lewis RJ, Nilsson MK, Öster L, Pemberton J, Ripa L, Storer RI, Käck H. Di Fruscia P, et al. Among authors: lewis rj. ACS Med Chem Lett. 2021 Jan 27;12(2):302-308. doi: 10.1021/acsmedchemlett.0c00563. eCollection 2021 Feb 11. ACS Med Chem Lett. 2021. PMID: 33603979 Free PMC article.
Identification and Optimization of Pyrrolidine Derivatives as Highly Potent Ghrelin Receptor Full Agonists.
Cooper M, Llinas A, Hansen P, Caffrey M, Ray A, Sjödin S, Shamovsky I, Wada H, Jellesmark Jensen T, Sivars U, Hultin L, Andersson U, Lundqvist S, Gedda K, Jinton L, Krutrök N, Lewis R, Jansson P, Gardelli C. Cooper M, et al. J Med Chem. 2020 Sep 10;63(17):9705-9730. doi: 10.1021/acs.jmedchem.0c00828. Epub 2020 Aug 27. J Med Chem. 2020. PMID: 32787075
1,058 results