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Discovery and development of CPL207280 as new GPR40/FFA1 agonist.
Mach M, Bazydło-Guzenda K, Buda P, Matłoka M, Dzida R, Stelmach F, Gałązka K, Wąsińska-Kałwa M, Smuga D, Hołowińska D, Dawid U, Gurba-Bryśkiewicz L, Wiśniewski K, Dubiel K, Pieczykolan J, Wieczorek M. Mach M, et al. Among authors: stelmach f. Eur J Med Chem. 2021 Dec 15;226:113810. doi: 10.1016/j.ejmech.2021.113810. Epub 2021 Sep 1. Eur J Med Chem. 2021. PMID: 34537444
CPL207280, a Novel G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1-Specific Agonist, Shows a Favorable Safety Profile and Exerts Antidiabetic Effects in Type 2 Diabetic Animals.
Bazydlo-Guzenda K, Buda P, Matloka M, Mach M, Stelmach F, Dzida R, Smuga D, Hucz-Kalitowska J, Teska-Kaminska M, Vialichka V, Dubiel K, Kaminska B, Wieczorek M, Pieczykolan J. Bazydlo-Guzenda K, et al. Among authors: stelmach f. Mol Pharmacol. 2021 Oct;100(4):335-347. doi: 10.1124/molpharm.121.000260. Epub 2021 Aug 4. Mol Pharmacol. 2021. PMID: 34349026